| Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. | |
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MedLine Citation:
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PMID: 17215379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The "small baby syndrome hypothesis" suggests that an inverse linear relation exists between birth weight and risk of type 2 diabetes. The authors conducted a meta-analysis to examine this association. They included studies that reported odds ratios and 95% confidence intervals (or data with which to calculate them) for the association of type 2 diabetes with birth weight. Fourteen studies involving a total of 132,180 persons were identified. Low birth weight (<2,500 g), as compared with a birth weight of >/=2,500 g, was associated with increased risk of type 2 diabetes (odds ratio (OR) = 1.32, 95% confidence interval (CI): 1.06, 1.64). High birth weight (>4,000 g), as compared with a birth weight of </=4,000 g, was associated with increased risk to the same extent (OR = 1.27, 95% CI: 1.01, 1.59). Pooled estimates increased further when normal birth weight (2,500-4,000 g) was used as the reference category (low birth weight: OR = 1.47, 95% CI: 1.26, 1.72; high birth weight: OR = 1.36, 95% CI: 1.07, 1.73). Meta-regression and categorical analyses showed a U-shaped relation between birth weight and diabetes risk. These findings indicate that there exists a relation between birth weight and later-life risk of type 2 diabetes which is not linearly inverse but U-shaped. |
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Authors:
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Thomas Harder; Elke Rodekamp; Karen Schellong; Joachim W Dudenhausen; Andreas Plagemann |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2007-01-10 |
Journal Detail:
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Title: American journal of epidemiology Volume: 165 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-30 Completed Date: 2007-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 849-57 Citation Subset: IM |
Affiliation:
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Obstetrics Clinic, "Experimental Obstetrics" Research Group, Charité-University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight* Diabetes Mellitus, Type 2 / epidemiology* Humans Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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