Document Detail


Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population.
MedLine Citation:
PMID:  20412481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Although congenital heart disease is associated with low birth weight and prematurity, there is little information about these birth outcomes in infants with single ventricle physiology. We describe the birth outcomes (i.e., gestational age and birth weight) in neonates with single ventricle physiology screened for enrollment in the Pediatric Heart Network's Infant Single Ventricle Trial, compare these outcomes with US norms, and examine the association of birth outcomes with anatomic diagnosis and race.
PATIENTS AND METHODS: All neonates with single ventricle physiology presenting to Infant Single Ventricle Trial centers were screened for enrollment. Demographic data and anatomic diagnoses were obtained from medical records.
RESULTS: A total of 1245 neonates with single ventricle physiology were screened at 10 centers (63 to 266 per center). Diagnoses included hypoplastic left heart syndrome in 49%, unbalanced atrioventricular septal defect in 12%, and tricuspid atresia in 9%. Preterm birth occurred in 16% of neonates with single ventricle physiology vs. 12% in normal neonates (P < .001), low birth weight (<2.5 kg) in 18% vs. 8% in normals (P < .001), and small for gestational age (<10th percentile by definition) in 22% vs. 10% in normals (P < .001). A genetic syndrome was reported in 8%. The percentage of preterm birth, low birth weight, and small for gestational age was similar between screened neonates with and without hypoplastic left heart syndrome.
CONCLUSIONS: In this large, contemporary cohort of neonates with single ventricle physiology, rates of preterm birth, low birth weight, and small for gestational age were higher than in the general population, but similar between screened neonates with and without hypoplastic left heart syndrome.
Authors:
Richard V Williams; Chitra Ravishankar; Victor Zak; Frank Evans; Andrew M Atz; William L Border; Jami Levine; Jennifer S Li; Lynn Mahony; Seema Mital; Gail D Pearson; Ashwin Prakash; Daphne T Hsu;
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Congenital heart disease     Volume:  5     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-20     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-103     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA. richard.williams@imail.org
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MeSH Terms
Descriptor/Qualifier:
Birth Weight*
Female
Gestational Age
Heart Defects, Congenital / complications*
Heart Ventricles / abnormalities*
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Infant, Small for Gestational Age
Male
Randomized Controlled Trials as Topic
Grant Support
ID/Acronym/Agency:
U01 HL068269/HL/NHLBI NIH HHS; U01 HL068270/HL/NHLBI NIH HHS; U01 HL068279/HL/NHLBI NIH HHS; U01 HL068281/HL/NHLBI NIH HHS; U01 HL068285/HL/NHLBI NIH HHS; U01 HL068288/HL/NHLBI NIH HHS; U01 HL068290/HL/NHLBI NIH HHS; U01 HL068292/HL/NHLBI NIH HHS; U01 HL068292-09/HL/NHLBI NIH HHS; U01 HL085057/HL/NHLBI NIH HHS
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