Document Detail


Birth weight is associated with placental fat mass- and obesity-associated gene expression and promoter methylation in a Chinese population.
MedLine Citation:
PMID:  25394615     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To explore the relationship between birth weight and fat mass- and obesity-associated (FTO) gene expression and promoter methylation status in the Chinese population. Methods: Seventy-five neonates and their mothers were recruited from Yuying Children's Hospital of Wenzhou Medical University. Subjects were divided into three groups by birth weight: low (<3500 g, n=20), medium (3500-3999 g, n=30) and high (≥4000 g, n=25). Placental FTO transcript levels and promoter methylation were determined by quantitative PCR and Sequenom MassARRAY®. Results: Placental FTO mRNA expression was significantly increased in the High- and Medium-weight groups compared to the Low-weight group (P=0.023). Methylation rates of CpG11 sites were significantly decreased in high-birth weight newborns (P=0.018). Multiple linear regressions showed placental FTO mRNA, maternal pre-pregnancy BMI, and CpG11 methylation rate were independently associated with increased fetal birth weight. Additionally, FTO mRNA expression was negatively associated with CpG6.7.8.9 methylation in mothers that underwent C-section. Conclusions: High placental FTO expression is associated with increased birth weight in Chinese neonates, and FTO promoter methylation level at a specific CpG site is negatively associated with birth weight. Further work is needed to determine the functionality of this CpG site in placentas.
Authors:
Liu Zi-Wei; Zhang Ji-Tai; Cai Qian-Ying; Zhang Heng-Xin; Wang Yu-Huan; Yan Hong-Tao; Wu Hong-Mei; Yang Xin-Jun
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-14
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-14     Completed Date:  -     Revised Date:  2014-11-15    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-20     Citation Subset:  -    
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