Document Detail

Birth-related increase in intracolonic hydrogen gas and nitric oxide as indicator of host-microbial interactions.
MedLine Citation:
PMID:  15679729     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bacterial colonization of the intestine early in life might have implications for allergy development. We studied early host-bacterial interactions in the gut by simultaneous measurements of hydrogen gas (H(2)) and faecal short chain fatty acid pattern (SCFAs), i.e. bacterial products, as well as of nitric oxide (NO), a marker of mucosal immune activation. METHODS: A novel minimally invasive technique was used for repeated measurements of luminal colonic H(2) and NO in 32 healthy newborn infants delivered vaginally or by Caesarean section. Luminal gas was sampled and analysed at five occasions: immediately after birth, day 1, days 3-5, 1 and 5-6 months after birth. RESULTS: Colonic H(2), NO and faecal SCFAs were undetectable at birth. The H(2) and SCFAs appeared within 24 h and continued to increase during the 6 months follow-up. Nitric oxide remained very low until 3-5 days after birth at which time it markedly increased. In some apparently healthy infants NO transiently reached levels similar to those seen in adults with inflammatory bowel disease. CONCLUSION: Intracolonic measurements of H(2) and NO may be useful to monitor the developmental colonization process as well as mucosal responses.
T Sobko; M Norman; E Norin; L E Gustafsson; J O Lundberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  60     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2005-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  396-400     Citation Subset:  IM    
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Bacteria / metabolism*
Colon / metabolism*,  microbiology*
Fatty Acids, Volatile / analysis
Feces / chemistry
Gases / metabolism
Hydrogen / metabolism*
Infant, Newborn
Nitric Oxide / metabolism*
Time Factors
Reg. No./Substance:
0/Fatty Acids, Volatile; 0/Gases; 10102-43-9/Nitric Oxide; 1333-74-0/Hydrogen

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