Document Detail


Birth prevalence and natural history of congenital cytomegalovirus infection in a highly seroimmune population.
MedLine Citation:
PMID:  19583520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The natural history of congenital cytomegalovirus (CMV) infection is scarcely known in populations with high maternal CMV seroprevalence. This study evaluated the birth prevalence, clinical findings at birth, and hearing outcome in CMV-infected children from such a population.
METHODS: Consecutively born infants were screened for the presence of CMV in urine and/or saliva specimens during the first 2 weeks after birth. Neonatal clinical findings were recorded, and CMV-infected children were tested to document hearing function during follow-up. A subset of mothers of CMV-infected infants were prenatally tested for the presence of anti-CMV immunoglobulin G antibodies.
RESULTS: Congenital CMV infection was confirmed in 87 (1.08%; 95% confidence interval [CI], 0.86%-1.33%) of 8047 infants. Seven infants (8.1%; 95% CI, 3.3%-15.9%) had at least 1 clinical finding suggestive of CMV infection, and 4 (4.6%; 95% CI, 1.3%-11.3%) had >3 findings of systemic disease. Sensorineural hearing loss was found in 5 (8.6%; 95% CI, 2.9%-19.0%) of 58 children tested at a median age of 21 months. Bilateral profound hearing loss was observed in 2 children, and the hearing threshold was >60 decibels in all 5 children with hearing loss, including 2 children born to mothers with probable nonprimary CMV infection.
CONCLUSIONS: The results of this large newborn screening study in a population with high CMV seroimmunity provide additional evidence that congenital CMV disease occurs in populations with high seroprevalence rates, with a similar incidence of CMV-related hearing loss to that reported in the offspring of women from populations in developed countries with lower rates of seroimmunity to CMV.
Authors:
Marisa M Mussi-Pinhata; Aparecida Y Yamamoto; Rosângela M Moura Brito; Myriam de Lima Isaac; Patricia F de Carvalho e Oliveira; Suresh Boppana; William J Britt
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  49     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-09-14     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  522-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / epidemiology*,  pathology,  virology
Female
Hearing Tests
Humans
Infant, Newborn
Infant, Newborn, Diseases / epidemiology*,  pathology,  virology*
Male
Pregnancy
Prevalence
Saliva / virology
Urine / virology
Young Adult
Grant Support
ID/Acronym/Agency:
AI49537/AI/NIAID NIH HHS; R01 AI049537/AI/NIAID NIH HHS; R01 AI049537-01A1/AI/NIAID NIH HHS; R01 AI089956/AI/NIAID NIH HHS; R01 HD061959/HD/NICHD NIH HHS; R01 NS065845/NS/NINDS NIH HHS; R03 TW006480/TW/FIC NIH HHS; R03 TW006480-01A1/TW/FIC NIH HHS
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