Document Detail

Birth prevalence of malformations in members of different ethnic groups and in the offspring of matings between them, in Birmingham, England.
MedLine Citation:
PMID:  7798046     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: The aims were: (1) to compare the birth prevalence of malformations in different ethnic groups and (2) to explore the reasons for the ethnic variations found by examining birth prevalence in the offspring of matings between ethnic groups. DESIGN: Analysis of data from a register of malformations and register of births. SETTING: Birmingham, England. SUBJECTS: A total of 432,778 infants (including stillbirths) born in 1960-84. MAIN RESULTS: Significant differences (p < 0.01) between ethnic groups were exhibited by the birth prevalence of neural tube defects (NTD), cleft palate, cleft lip, oesophageal atresia/fistula, hypospadias, hip dislocation, clubfoot, polydactyly, and syndactyly. In the offspring of matings between parents of European and Caribbean origin, the birth prevalence of NTD, cleft lip, hypospadias, hip dislocation, polydactyly, and syndactyly seemed more likely to be influenced by the ethnicity of both parents than by that of the mother alone. The reverse was true for the birth prevalence of NTD in subjects with one parent of Irish origin and on of British. CONCLUSIONS: Genetic differences may be responsible for Europeans being at lower risk of polydactyly and at higher risk of NTD, cleft lip, hypospadias, hip dislocation, and syndactyly than Caribbeans. Variations in the intrauterine environment are more likely to account for NTD being more common in Irish than in British subjects.
I Leck; R J Lancashire
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of epidemiology and community health     Volume:  49     ISSN:  0143-005X     ISO Abbreviation:  J Epidemiol Community Health     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-07-31     Completed Date:  1995-07-31     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7909766     Medline TA:  J Epidemiol Community Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  171-9     Citation Subset:  IM    
University of Manchester.
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MeSH Terms
Asia / ethnology
Congenital Abnormalities / epidemiology,  ethnology*
England / epidemiology
Great Britain / ethnology
Infant, Newborn
Ireland / ethnology
West Indies / ethnology
Erratum In:
J Epidemiol Community Health 1995 Aug;49(4):443

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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