Document Detail


Birth prevalence of congenital hypothyroidism in Mexico.
MedLine Citation:
PMID:  18782254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Mexican Institute of Social Security (IMSS) provides care for more than 40% of the Mexican population. This report constitutes the first study of the incidence of congenital hypothyroidism (CH) in Mexican children. We performed a prospective study with a population base. CH screening began in 1997 with blood samples from the heel taken 72 h after birth; from 2000, the detection strategy was changed nationwide and blood samples were taken from the umbilical cord in all newborns for determination of thyroid-stimulating hormone (TSH) concentration. We evaluated the annual coverage. TSH concentration was measured by chemoluminescence; TSH values > or =30 microIU/mL in umbilical cord blood and 15 microIU/mL in capillary blood were considered positive cases and were confirmed through hormonal studies. The incidence and 95% confidence intervals [95% CI] were calculated. We found that coverage within the IMSS population was 53% from 1997 to 2000 and had increased to 95% by 2001. A total of 2,777,292 children from 2,975,157 births (93%) were studied between 2000 and 2004. Of these, 4050 had a high TSH concentration leading to suspicion of CH; CH was confirmed in 1286 (32%). The resulting incidence was 4.3/10,000 livebirths [95% CI 3.6, 5.1]. With the results obtained, we conclude that the IMSS strategy of CH screening at birth ensured 95% coverage of children in the system. The birth prevalence of CH reported is among the highest in the world.
Authors:
Mario E Rendón-Macías; Inés Morales-García; Emilio Huerta-Hernández; Anabel Silva-Batalla; Miguel A Villasís-Keever
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  22     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2008-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  478-85     Citation Subset:  IM    
Affiliation:
Unidad de Salud Pública, Coordinación de Programas Integrados de Salud, Hospital de Pediatría Centro Médico Nacional, Siglo XXI, México.
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MeSH Terms
Descriptor/Qualifier:
Congenital Hypothyroidism / diagnosis,  epidemiology*
Humans
Infant, Newborn
Mexico / epidemiology
Neonatal Screening / methods*
Predictive Value of Tests
Prospective Studies
Statistics as Topic
Thyrotropin / analysis*,  blood
Chemical
Reg. No./Substance:
9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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