| Birth prevalence of congenital hypothyroidism in Mexico. | |
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MedLine Citation:
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PMID: 18782254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Mexican Institute of Social Security (IMSS) provides care for more than 40% of the Mexican population. This report constitutes the first study of the incidence of congenital hypothyroidism (CH) in Mexican children. We performed a prospective study with a population base. CH screening began in 1997 with blood samples from the heel taken 72 h after birth; from 2000, the detection strategy was changed nationwide and blood samples were taken from the umbilical cord in all newborns for determination of thyroid-stimulating hormone (TSH) concentration. We evaluated the annual coverage. TSH concentration was measured by chemoluminescence; TSH values > or =30 microIU/mL in umbilical cord blood and 15 microIU/mL in capillary blood were considered positive cases and were confirmed through hormonal studies. The incidence and 95% confidence intervals [95% CI] were calculated. We found that coverage within the IMSS population was 53% from 1997 to 2000 and had increased to 95% by 2001. A total of 2,777,292 children from 2,975,157 births (93%) were studied between 2000 and 2004. Of these, 4050 had a high TSH concentration leading to suspicion of CH; CH was confirmed in 1286 (32%). The resulting incidence was 4.3/10,000 livebirths [95% CI 3.6, 5.1]. With the results obtained, we conclude that the IMSS strategy of CH screening at birth ensured 95% coverage of children in the system. The birth prevalence of CH reported is among the highest in the world. |
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Authors:
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Mario E Rendón-Macías; Inés Morales-García; Emilio Huerta-Hernández; Anabel Silva-Batalla; Miguel A Villasís-Keever |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Paediatric and perinatal epidemiology Volume: 22 ISSN: 1365-3016 ISO Abbreviation: Paediatr Perinat Epidemiol Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2008-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709766 Medline TA: Paediatr Perinat Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 478-85 Citation Subset: IM |
Affiliation:
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Unidad de Salud Pública, Coordinación de Programas Integrados de Salud, Hospital de Pediatría Centro Médico Nacional, Siglo XXI, México. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Hypothyroidism
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diagnosis,
epidemiology* Humans Infant, Newborn Mexico / epidemiology Neonatal Screening / methods* Predictive Value of Tests Prospective Studies Statistics as Topic Thyrotropin / analysis*, blood |
| Chemical | |
Reg. No./Substance:
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9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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