Document Detail

Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study.
MedLine Citation:
PMID:  17921364     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Birth weight has been shown to be positively associated with adult obesity, but relatively few studies have examined the associations with growth in specific periods of early childhood. OBJECTIVE: The objective was to assess the association of measures of growth between birth and 5 y of age with adult measures of adiposity. DESIGN: We conducted a longitudinal study of young adults from Barry and Caerphilly, United Kingdom, who had previously taken part between 1972 and 1974 in a randomized controlled trial of milk supplementation. We reexamined 679 men and women (72% of the target population) to measure body mass index (BMI; in kg/m(2)), waist-to-hip ratio, sagittal abdominal diameter, and waist circumference. RESULTS: An increase in weight velocity from 1 y and 9 mo to 5 y of age was the most important predictor of BMI, waist circumference, and sagittal abdominal diameter. A z-score increase in weight gain in this period was associated with an increase in BMI of 1.13 (95% CI: 0.69, 1.57; P < 0.001). Infant weight gain from 5 mo to 1 y and 9 mo was the strongest predictor of waist-to-hip ratio (0.51; 95% CI: 0.00, 1.02; P = 0.05). CONCLUSIONS: Birth weight does not predict adiposity on the basis of weight gain in childhood. The association between adult adiposity and weight gain in different periods is variable and depends on the measure of adiposity that is used. It remains unclear whether early childhood is the optimum period in the life course for the primary prevention of adult adiposity.
Anne McCarthy; Rachael Hughes; Kate Tilling; David Davies; George Davey Smith; Yoav Ben-Shlomo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  86     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-08     Completed Date:  2007-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  907-13     Citation Subset:  AIM; IM    
Department of Social Medicine, University of Bristol, Bristol, United Kingdom.
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MeSH Terms
Adipose Tissue / anatomy & histology,  metabolism
Aging / physiology
Birth Weight / physiology*
Body Composition / physiology*
Body Constitution / physiology
Body Mass Index
Child Development / physiology*
Child, Preschool
Follow-Up Studies
Infant, Newborn / growth & development*
Longitudinal Studies
Obesity / epidemiology*
Waist-Hip Ratio
Weight Gain / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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