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Birth outcomes following treatment for precancerous changes to the cervix: a population-based record linkage study.
MedLine Citation:
PMID:  21790951     Owner:  NLM     Status:  Publisher    
Please cite this paper as: Reilly R, Paranjothy S, Beer H, Brooks C, Fielder H, Lyons R. Birth outcomes following treatment for precancerous changes to the cervix: a population-based record linkage study. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.03052.x. Objective  To examine whether treatments for precancerous changes to the cervix are associated with adverse birth outcomes in subsequent pregnancies. Design  Population-based retrospective cohort study using electronic linkage of data from the Welsh cervical screening programme and a national routine child health database. Setting  Wales. Population  A total of 174 325 women aged 20-39 years who received cervical screening between April 2001 and March 2004. Methods  Logistic regression was used to compare the odds of each birth outcome between women who had negative cervical smears and women who received either colposcopy ± punch biopsy only or colposcopy and excisional or ablative treatments, adjusted for confounding factors (e.g. age, social deprivation and smoking). Main outcome measures  Preterm birth (before 37, 32 and 28 weeks of gestation), and low birthweight (<2500 g). Results  Compared with women who had negative cervical smears, the odds ratio for preterm birth (<37 weeks) was significantly increased in women who had colposcopy only (adjusted odds ratio 1.54, 95% CI 1.32-1.80) and single excisional treatment (adjusted odds ratio 1.77, 95% CI 1.47-2.13). Similar results were observed for preterm birth at <32 weeks of gestation. There was no increased risk of preterm birth or low birthweight for women who had treatment compared with women who had colposcopy only. Conclusion  Women who were referred for colposcopy had an increased risk of preterm births regardless of whether or not they received treatment to the cervix. This increased risk could be the result of common risk factors for abnormal smears and preterm birth.
R Reilly; S Paranjothy; H Beer; Cj Brooks; Hm Fielder; Ra Lyons
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-27
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.
 Public Health Wales NHS Trust  Clinical Epidemiology Interdisciplinary Research Group, School of Medicine, Cardiff University, Cardiff  Health Information Research Unit, College of Medicine, Swansea University, Swansea, UK.
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