Document Detail

Birth order and sibship size: evaluation of the role of selection bias in a case-control study of non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  17591593     Owner:  NLM     Status:  MEDLINE    
Substantial heterogeneity has been observed among case-control studies investigating associations between non-Hodgkin's lymphoma and familial characteristics, such as birth order and sibship size. The potential role of selection bias in explaining such heterogeneity is considered within this study. Selection bias according to familial characteristics and socioeconomic status is investigated within a United Kingdom-based case-control study of non-Hodgkin's lymphoma diagnosed during 1998-2001. Reported distributions of birth order and maternal age are each compared with expected reference distributions derived using national birth statistics from the United Kingdom. A method is detailed in which yearly data are used to derive expected distributions, taking account of variability in birth statistics over time. Census data are used to reweight both the case and control study populations such that they are comparable with the general population with regard to socioeconomic status. The authors found little support for an association between non-Hodgkin's lymphoma and birth order or family size and little evidence for an influence of selection bias. However, the findings suggest that between-study heterogeneity could be explained by selection biases that influence the demographic characteristics of participants.
F K Mensah; E V Willett; J Simpson; A G Smith; E Roman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-24
Journal Detail:
Title:  American journal of epidemiology     Volume:  166     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  717-23     Citation Subset:  IM    
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom.
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MeSH Terms
Birth Order*
Case-Control Studies
Family Characteristics*
Great Britain / epidemiology
Interviews as Topic
Likelihood Functions
Lymphoma, Non-Hodgkin / epidemiology*
Maternal Age
Middle Aged
Risk Factors
Selection Bias*
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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