Document Detail

Birth order and the severity of illness in schizophrenia.
MedLine Citation:
PMID:  17292486     Owner:  NLM     Status:  MEDLINE    
A proposed risk factor for schizophrenia is materno-foetal incompatibility. We tested the hypothesis that, in multiply affected families, later born children would exhibit a more severe form of schizophrenia than their older siblings. The effect of birth order on (1) severity of the worst ever episode of illness; (2) deterioration from premorbid level of functioning; (3) age of onset; (4) response to medication; and (5) illness course, was assessed in 150 sibling pairs with schizophrenia and schizoaffective disorder. We found that later birth order reduced the likelihood of regaining the premorbid level of functioning after an acute episode and was also associated with an earlier age of presentation. This study lends some support to the hypothesis that later birth order results in a more severe form of the disorder, although there are other possible explanations for our findings. Further work is needed to explore the possibility of maternal-foetal genotype incompatibility as a risk factor for schizophrenia.
Fiona Gaughran; Robert Blizard; Ramya Mohan; Stanley Zammit; Michael Owen
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Publication Detail:
Type:  Journal Article     Date:  2007-02-08
Journal Detail:
Title:  Psychiatry research     Volume:  150     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-07-16     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
Department of Psychological Medicine, King's College London, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, United Kingdom.
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MeSH Terms
Age Factors
Birth Order*
Chronic Disease
Follow-Up Studies
Middle Aged
Psychiatric Status Rating Scales
Psychotic Disorders / diagnosis,  genetics*,  psychology
Quality of Life / psychology
Rh Isoimmunization / diagnosis,  genetics*,  psychology
Risk Factors
Schizophrenia / diagnosis,  genetics*
Schizophrenic Psychology*
Social Adjustment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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