Document Detail


Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease.
MedLine Citation:
PMID:  18067015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rank order of affected offspring in a sibship can inform on epigenetic factors in disease susceptibility. Here we report an analysis of birth order in 32 families segregating chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative disorders. A paternal-offspring, but not a maternal-offspring birth rank order was observed. Cox regression analysis provided relative risks (RR) for paternal and maternal transmission of 3.60 (CI 95%: 1.54 - 8.42; P = 0.0005) and 1.64 (CI 95%: 0.90 - 3.01; P = 0.096), respectively. The significance of paternal and maternal transmission of CLL-CLL pairs employing Haldane and Smith's test were 0.006 and 0.63, respectively. There was no evidence of a relationship between parental age and birth order. The genetic mechanism behind the birth order effect observed is discussed in the light of non-Mendelian imprinting and pregnancy related microchimerism.
Authors:
Viggo Jønsson; Geir Tjønnfjord; Sven Ove Samuelsen; Tom Johannesen; Jørgen Olsen; Gabrielle Sellick; Richard Houlston; Martin Yuille; Daniel Catovsky
Related Documents :
12723145 - "rage to order": wallace stevens and hans loewald.
10883715 - Intra-uterine physical growth in schizophrenia: evidence confirming excess of premature...
14988645 - Neurocognitive models of schizophrenia: a neurophenomenological critique.
1544015 - Season of birth of siblings of schizophrenic patients.
1240015 - Selective induction of labour.
15296585 - Factors influencing the breastfeeding decisions of long-term breastfeeders.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  48     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  2387-96     Citation Subset:  IM    
Affiliation:
Haematology Department, Aker University Hospital, University of Oslo, Norway. viggo.jonsson@medisin.uio.no
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Birth Order*
Epigenesis, Genetic
Female
Genomic Imprinting
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Lymphoproliferative Disorders / genetics*
Male
Middle Aged
Regression Analysis
Comments/Corrections
Comment In:
Leuk Lymphoma. 2007 Dec;48(12):2306-7   [PMID:  18067003 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Estimated number of cases, regional distribution and survival of patients diagnosed with acute myelo...
Next Document:  Biologic predictors in follicular lymphoma: importance of markers of immune response.