Document Detail

Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease.
MedLine Citation:
PMID:  18067015     Owner:  NLM     Status:  MEDLINE    
Rank order of affected offspring in a sibship can inform on epigenetic factors in disease susceptibility. Here we report an analysis of birth order in 32 families segregating chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative disorders. A paternal-offspring, but not a maternal-offspring birth rank order was observed. Cox regression analysis provided relative risks (RR) for paternal and maternal transmission of 3.60 (CI 95%: 1.54 - 8.42; P = 0.0005) and 1.64 (CI 95%: 0.90 - 3.01; P = 0.096), respectively. The significance of paternal and maternal transmission of CLL-CLL pairs employing Haldane and Smith's test were 0.006 and 0.63, respectively. There was no evidence of a relationship between parental age and birth order. The genetic mechanism behind the birth order effect observed is discussed in the light of non-Mendelian imprinting and pregnancy related microchimerism.
Viggo Jønsson; Geir Tjønnfjord; Sven Ove Samuelsen; Tom Johannesen; Jørgen Olsen; Gabrielle Sellick; Richard Houlston; Martin Yuille; Daniel Catovsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  48     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  2387-96     Citation Subset:  IM    
Haematology Department, Aker University Hospital, University of Oslo, Norway.
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MeSH Terms
Birth Order*
Epigenesis, Genetic
Genomic Imprinting
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Lymphoproliferative Disorders / genetics*
Middle Aged
Regression Analysis
Comment In:
Leuk Lymphoma. 2007 Dec;48(12):2306-7   [PMID:  18067003 ]

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