| Birth of neural progenitors during the embryonic period of sexual differentiation in the Japanese quail brain. | |
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MedLine Citation:
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PMID: 22628012 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Several brain areas in the diencephalon are involved in the activation and expression of sexual behavior, including in quail, the medial preoptic nucleus (POM). However, the ontogeny of these diencephalic brain nuclei has not to this date been examined in detail. We investigated the ontogeny of POM and other steroid-sensitive brain regions by injecting quail eggs with 5-bromo-2-deoxyuridine (BrdU) at various stages between E3 and E16 and killing animals at postnatal (PN) days 3 or 56. In the POM, large numbers of BrdU-positive cells were observed in subjects injected from E3 to E10, the numbers of these cells was intermediate in birds injected on E12, and most cells were post-mitotic in both sexes on E14-E16. Injections on E3-E4 labeled large numbers of Hu positive cells in POM. In contrast, injections performed at a later stage labeled cells that do not express aromatase nor neuronal markers such as Hu or NeuN in the POM and other steroid-sensitive nuclei and thus do not have a neuronal phenotype in these locations contrary to what is observed in the telencephalon and cerebellum. No evidence could also be collected to demonstrate that these cells have a glial nature. Converging data, including the facts that these cells divide in the brain mantle and express PCNA, a cell cycling marker, indicate that cells labeled by BrdU during the second half of embryonic life are slow cycling progenitors born and residing in the brain mantle. Future research should now identify their functional significance. J. Comp. Neurol., 2012. © 2012 Wiley-Liss, Inc. |
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Authors:
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Sylvia M Bardet; Karen Mouriec; Jacques Balthazart |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-24 |
Journal Detail:
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Title: The Journal of comparative neurology Volume: - ISSN: 1096-9861 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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GIGA Neurosciences, Research Group in Behavioral Neuroendocrinology, University of Liège, Liège, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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