Document Detail


Birth and expression evolution of mammalian microRNA genes.
MedLine Citation:
PMID:  23034410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their origins and functional evolution in mammals remain little understood due to the lack of appropriate comparative data. Using RNA sequencing, we have generated extensive and comparable miRNA data for five organs in six species that represent all main mammalian lineages and birds (the evolutionary outgroup) with the aim to unravel the evolution of mammalian miRNAs. Our analyses reveal an overall expansion of miRNA repertoires in mammals, with threefold accelerated birth rates of miRNA families in placentals and marsupials, facilitated by the de novo emergence of miRNAs in host gene introns. Generally, our analyses suggest a high rate of miRNA family turnover in mammals with many newly emerged miRNA families being lost soon after their formation. Selectively preserved mammalian miRNA families gradually evolved higher expression levels, as well as altered mature sequences and target gene repertoires, and were apparently mainly recruited to exert regulatory functions in nervous tissues. However, miRNAs that originated on the X chromosome evolved high expression levels and potentially diverse functions during spermatogenesis, including meiosis, through selectively driven duplication-divergence processes. Overall, our study thus provides detailed insights into the birth and evolution of mammalian miRNA genes and the associated selective forces.
Authors:
Julien Meunier; Frédéric Lemoine; Magali Soumillon; Angélica Liechti; Manuela Weier; Katerina Guschanski; Haiyang Hu; Philipp Khaitovich; Henrik Kaessmann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Genome research     Volume:  23     ISSN:  1549-5469     ISO Abbreviation:  Genome Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-06-11     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9518021     Medline TA:  Genome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-45     Citation Subset:  IM    
Affiliation:
Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Julien.Meunier@unil.ch
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE40499
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens
Evolution, Molecular*
Gene Expression / genetics*
Humans
Introns
Macaca
Mice
MicroRNAs / classification,  genetics*
Multigene Family
Opossums
Phylogeny
Platypus
X Chromosome / genetics
Chemical
Reg. No./Substance:
0/MicroRNAs
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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