Document Detail

Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis.
MedLine Citation:
PMID:  6650593     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that the use of Bendectin in pregnancy increases the risk of pyloric stenosis, we determined rates of antenatal Bendectin exposure among 325 infants with pyloric stenosis and among two control groups comprising infants with other defects; one consisted of 3,153 infants with other conditions, and the other, a subset of that group, consisted of 724 infants with defects that may have had their origins at any time in pregnancy. Comparisons between the cases and the two control series yielded estimated relative risks of 0.9 (95% confidence interval, 0.6 to 1.2) and 1.0 (0.7 to 1.4), respectively. The findings from this large case-control study suggest that Bendectin does not increase the risk of pyloric stenosis.
A A Mitchell; P J Schwingl; L Rosenberg; C Louik; S Shapiro
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  147     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2010-07-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  737-42     Citation Subset:  AIM; IM    
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Doxylamine / adverse effects*
Drug Combinations / adverse effects
Hyperemesis Gravidarum / drug therapy
Maternal-Fetal Exchange
Prenatal Care
Pyloric Stenosis / chemically induced*,  genetics
Pyridines / adverse effects*
Pyridoxine / adverse effects*
Sex Factors
Grant Support
223-76-3016//PHS HHS; 223-80-3001//PHS HHS; 226-82-0007//PHS HHS
Reg. No./Substance:
0/Drug Combinations; 0/Pyridines; 0/dicyclomine, doxylamine, pyridoxine drug combination; 469-21-6/Doxylamine; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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