| Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis. | |
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MedLine Citation:
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PMID: 6650593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that the use of Bendectin in pregnancy increases the risk of pyloric stenosis, we determined rates of antenatal Bendectin exposure among 325 infants with pyloric stenosis and among two control groups comprising infants with other defects; one consisted of 3,153 infants with other conditions, and the other, a subset of that group, consisted of 724 infants with defects that may have had their origins at any time in pregnancy. Comparisons between the cases and the two control series yielded estimated relative risks of 0.9 (95% confidence interval, 0.6 to 1.2) and 1.0 (0.7 to 1.4), respectively. The findings from this large case-control study suggest that Bendectin does not increase the risk of pyloric stenosis. |
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Authors:
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A A Mitchell; P J Schwingl; L Rosenberg; C Louik; S Shapiro |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 147 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-01-07 Completed Date: 1984-01-07 Revised Date: 2010-07-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 737-42 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Doxylamine / adverse effects* Drug Combinations / adverse effects Female Humans Hyperemesis Gravidarum / drug therapy Infant Male Maternal-Fetal Exchange Pregnancy Prenatal Care Pyloric Stenosis / chemically induced*, genetics Pyridines / adverse effects* Pyridoxine / adverse effects* Questionnaires Risk Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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223-76-3016//PHS HHS; 223-80-3001//PHS HHS; 226-82-0007//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Pyridines; 0/dicyclomine, doxylamine, pyridoxine drug combination; 469-21-6/Doxylamine; 65-23-6/Pyridoxine |
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