Document Detail


Birth characteristics, maternal reproductive history, and the risk of infant leukemia: a report from the Children's Oncology Group.
MedLine Citation:
PMID:  17220341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukemias with MLL gene rearrangements predominate in infants (<1 year of age), but not in older children, and may have a distinct etiology. High birth weight, higher birth order, and prior fetal loss have, with varying consistency, been associated with infant leukemia, but no studies have reported results with respect to MLL status. Here, we report for the first time such an analysis. During 1999 to 2003, mothers of 240 incident cases (113 MLL(+), 80 MLL(-), and 47 indeterminate) and 255 random digit dialed controls completed a telephone interview. Odds ratios and 95% confidence intervals for quartile of birth weight, birth order, gestational age, maternal age at delivery, prior fetal loss, pre-pregnancy body mass index, and weight gain during pregnancy were obtained using unconditional logistic regression; P for linear trend was obtained by modeling continuous variables. There was a borderline significant linear trend of increasing birth weight with MLL(+) (P = 0.06), but not MLL(-) (P = 0.93), infant leukemia. Increasing birth order showed a significant inverse linear trend, independent of birth weight, with MLL(+) (P = 0.01), but not MLL(-) (P = 0.18), infant leukemia. Other variables of interest were not notably associated with infant leukemia regardless of MLL status. This investigation further supports the contention that molecularly defined subtypes of infant leukemia have separate etiologies.
Authors:
Logan G Spector; Stella M Davies; Leslie L Robison; Joanne M Hilden; Michelle Roesler; Julie A Ross
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  16     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-06-29     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-34     Citation Subset:  IM    
Affiliation:
Division of Epidemiology/Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware Street Southeast, MMC 715, Minneapolis, MN 55455, USA. spector@epi.umn.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Order
Birth Weight
Case-Control Studies
Child
DNA Damage
Female
Gene Rearrangement*
Humans
Infant, Newborn
Leukemia / epidemiology,  genetics*
Mothers*
Myeloid-Lymphoid Leukemia Protein / genetics*
Pregnancy
Reproductive History*
Risk Factors
United States
Grant Support
ID/Acronym/Agency:
R01 CA079940/CA/NCI NIH HHS; R01CA79940/CA/NCI NIH HHS; U10CA13539/CA/NCI NIH HHS; U10CA98543/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/MLL protein, human; 149025-06-9/Myeloid-Lymphoid Leukemia Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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