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Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines.
MedLine Citation:
PMID:  22375624     Owner:  NLM     Status:  Publisher    
Background:  The study was undertaken to compare the effects of vaginal delivery and cesarean section on the l-arginine-NO system by measuring levels of l-arginine, an endogenous nitric oxide synthase antagonist asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) levels in the cord blood and postnatally. Methods:  Plasma samples were obtained from the umbilical vein and artery at birth and from peripheral venous blood on the second postnatal day in 30 full-term newborn infants 10 born vaginally and 20 born by cesarean section. Results:  After vaginal delivery, ADMA concentration was higher in the umbilical vein than in the umbilical artery mean 1.06 vs 0.90 µmol/L (p = 0.027); ADMA level fell after birth to 0.66 µmol/L on the second postnatal day (p = 0.007 vs umbilical artery). Newborns born by cesarean section had similar ADMA levels in umbilical arterial and venous blood, 1.19 and 1.18 µmol/L, and the ADMA level fell to 0.84 µmol/L by the second postnatal day (p < 0.001). Vaginal birth induced neither significant umbilical veno-arterial difference nor a postnatal fall in SDMA. After cesarean section, SDMA was essentially the same in umbilical vein, umbilical artery and postnatal peripheral vein samples. At 2 days of age, both ADMA and SDMA levels stayed higher in infants born by cesarean section than in vaginally born infants. Conclusions:  ADMA level falls after both vaginal and cesarean birth, whereas SDMA level does not. The higher ADMA level after cesarean birth compared with vaginal birth may contribute to decreased NO production and bioavailability in neonatal vascular beds. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Gabriella Vida; Endre Sulyok; Tibor Ertl; Jeans Martens-Lobenhoffer; Stefanie M Bode-Böger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-29
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pecs, Pecs, Hungary Institute of Health Promotion and Family Care, Faculty of Health Sciences, University of Pecs, Pecs, Hungary Department of Clinical Pharmacology, University of Magdeburg, Magdeburg, Germany.
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