Document Detail

Birth weight, postnatal weight change, and risk for high blood pressure among chinese children.
MedLine Citation:
PMID:  21502227     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is hypothesized that a physiological predisposition toward hypertension results from a combination of intrauterine growth restriction or overgrowth and excessive postnatal weight gain. Previous studies were conducted largely in Western countries however the hypothesis may also be relevant in developing countries where metabolic disorders are increasing.
OBJECTIVE: We investigated the association of birth weight and postnatal weight gain with hypertension among Chinese children.
METHODS: A population based study was conducted among 15 600 children aged 3 to 6 years from Tianjin, China. Weight was expressed as z scores. Postnatal weight gain was defined as changes in z scores from birth to 3 to younger than 4 years, 4 to younger than 5 years, and 5 to 6 years. Hypertension was defined as greater than the 90th percentile of either systolic or diastolic blood pressure. Logistic regression-derived odds ratios and 95% confidence intervals were generated to estimate the association between birth weight and postnatal weight gain with hypertension risk in childhood.
RESULTS: Birth weight was positively associated with childhood hypertension in boys and girls (odds ratios [95% confidence interval] comparing extreme quartiles [high versus low] were 5.67 [3.83-8.39] and 2.58 [3.83-8.39], respectively). Postnatal weight gain was positively associated with hypertension and the association did not significantly vary by birth size for gestational age.
CONCLUSIONS: Greater birth weight or postnatal weight gain was associated with increased childhood hypertension risk, suggesting that intrauterine growth and postnatal weight gain may have implications on health during childhood.
Katherine Bowers; Gongshu Liu; Ping Wang; Tao Ye; Zhen Tian; Enqing Liu; Zhijie Yu; Xilin Yang; Mark Klebanoff; Edwina Yeung; Gang Hu; Cuilin Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2011-04-18
Journal Detail:
Title:  Pediatrics     Volume:  127     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-07-11     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1272-9     Citation Subset:  AIM; IM    
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20852, USA.
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MeSH Terms
Age Distribution
Asian Continental Ancestry Group / statistics & numerical data*
Birth Weight*
Blood Pressure Determination
Child Development / physiology
Child, Preschool
Cohort Studies
Confidence Intervals
Hypertension / epidemiology,  ethnology*,  physiopathology
Infant, Newborn
Logistic Models
Longitudinal Studies
Multivariate Analysis
Odds Ratio
Retrospective Studies
Risk Assessment
Sex Distribution
Weight Gain*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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