|Birth weight, postnatal weight change, and risk for high blood pressure among chinese children.|
|PMID: 21502227 Owner: NLM Status: MEDLINE|
|BACKGROUND: It is hypothesized that a physiological predisposition toward hypertension results from a combination of intrauterine growth restriction or overgrowth and excessive postnatal weight gain. Previous studies were conducted largely in Western countries however the hypothesis may also be relevant in developing countries where metabolic disorders are increasing.
OBJECTIVE: We investigated the association of birth weight and postnatal weight gain with hypertension among Chinese children.
METHODS: A population based study was conducted among 15 600 children aged 3 to 6 years from Tianjin, China. Weight was expressed as z scores. Postnatal weight gain was defined as changes in z scores from birth to 3 to younger than 4 years, 4 to younger than 5 years, and 5 to 6 years. Hypertension was defined as greater than the 90th percentile of either systolic or diastolic blood pressure. Logistic regression-derived odds ratios and 95% confidence intervals were generated to estimate the association between birth weight and postnatal weight gain with hypertension risk in childhood.
RESULTS: Birth weight was positively associated with childhood hypertension in boys and girls (odds ratios [95% confidence interval] comparing extreme quartiles [high versus low] were 5.67 [3.83-8.39] and 2.58 [3.83-8.39], respectively). Postnatal weight gain was positively associated with hypertension and the association did not significantly vary by birth size for gestational age.
CONCLUSIONS: Greater birth weight or postnatal weight gain was associated with increased childhood hypertension risk, suggesting that intrauterine growth and postnatal weight gain may have implications on health during childhood.
|Katherine Bowers; Gongshu Liu; Ping Wang; Tao Ye; Zhen Tian; Enqing Liu; Zhijie Yu; Xilin Yang; Mark Klebanoff; Edwina Yeung; Gang Hu; Cuilin Zhang|
|Type: Journal Article; Research Support, N.I.H., Intramural Date: 2011-04-18|
|Title: Pediatrics Volume: 127 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2011 May|
|Created Date: 2011-05-02 Completed Date: 2011-07-11 Revised Date: 2013-06-30|
Medline Journal Info:
|Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States|
|Languages: eng Pagination: e1272-9 Citation Subset: AIM; IM|
|Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20852, USA.|
|APA/MLA Format Download EndNote Download BibTex|
Asian Continental Ancestry Group / statistics & numerical data*
Blood Pressure Determination
Child Development / physiology
Hypertension / epidemiology, ethnology*, physiopathology
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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