Document Detail


Birth weight and adult hypercholesterolemia: subgroups of small-for-gestational-age based on maternal smoking status during pregnancy.
MedLine Citation:
PMID:  20798636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Being born small-for-gestational-age (SGA) is associated with hypercholesterolemia in later life. It is possible that only certain subgroups of SGA are at elevated risk for hypercholesterolemia. We examined the associations between SGA subgroups based on levels of maternal smoking during pregnancy and adult hypercholesterolemia.
METHODS: A subsample of 1625 adult offspring from the Collaborative Perinatal Project were followed at mean age 39 years. Subjects were classified by recorded fetal growth and maternal smoking status during pregnancy. Clinical diagnosis of hypercholesterolemia was obtained in interviews.
RESULTS: Compared with the appropriate-for-gestational-age subgroup without maternal smoking during pregnancy, only SGA subgroups with maternal smoking during pregnancy had higher risk of hypercholesterolemia: for heavy smoking, adjusted hazard ratio = 2.5 (95% confidence interval = 1.4-4.3); moderate smoking, 1.7 (1.0-2.8); nonsmoking, 1.1 (0.5-2.1).
CONCLUSION: Only SGA infants whose mothers smoked during pregnancy had elevated risk of hypercholesterolemia in adulthood.
Authors:
Xiaozhong Wen; Elizabeth W Triche; Joseph W Hogan; Edmond D Shenassa; Stephen L Buka
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  21     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  786-90     Citation Subset:  IM    
Affiliation:
Epidemiology Section, Department of Community Health, Brown University, Providence, RI 02912, USA. xiaozhongwen@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Birth Weight*
Female
Humans
Hypercholesterolemia / epidemiology,  physiopathology*
Infant, Newborn
Infant, Small for Gestational Age*
Male
Maternal Exposure
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Smoking / physiopathology*
United States / epidemiology
Grant Support
ID/Acronym/Agency:
P50 CA084719/CA/NCI NIH HHS; R40MC03600-01-00//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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