Document Detail


Birdshot chorioretinopathy: long-term manifestations and visual prognosis.
MedLine Citation:
PMID:  15121374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To ascertain the clinical features and long-term visual prognosis of birdshot chorioretinopathy (BCR), and to identify patients at risk of visual loss. DESIGN: Retrospective noncomparative case series. PARTICIPANTS: Fifty-five consecutive patients with HLA-A29-positive BCR who were identified in ophthalmology departments of the University Medical Center of Utrecht and The Eye Hospital Rotterdam, of whom 37 were observed for at least 5 years. INTERVENTION: A review of the medical and photographic and/or angiographic records of 55 patients with HLA-A29-positive BCR. MAIN OUTCOME MEASURES: Numerous variables were compared, including age and gender distribution, onset and course of BCR, ocular manifestations, therapeutic strategies and their outcomes, complications, systemic diseases, visual acuity (VA), and features associated with poor visual outcome. RESULTS: Loss of VA was gradual; the number of affected eyes with VA less than 20/200 increased from 9 of 108 (8%) at onset to 22 of 73 (30%) at 5 years and 19 of 49 (39%) at 10 years of follow-up. The cause of compromised VA was predominantly macular edema and macular atrophy (42 of 55 [76% of cases]). We found strong associations between the VA at onset and visual outcome after 5 and 10 years (P = 0.005 and P = 0.006, respectively). Mean VA at the 5-year follow-up was significantly lower if macular leakage was observed on angiography (P<0.001). No differences in annual loss of VA were observed between patients treated by standard therapeutic modalities and untreated patients. CONCLUSION: The visual prognosis of BCR in a spectrum of uveitis is poor, and the recommended therapeutic regimens have had no effect on long-term visual prognosis. New treatment strategies are needed for this blinding disorder.
Authors:
Aniki Rothova; Tos T J M Berendschot; Kiki Probst; Bram van Kooij; G Seerp Baarsma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmology     Volume:  111     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  954-9     Citation Subset:  IM    
Affiliation:
Uveitis Center, F. C. Donders Institute of Ophthalmology, University Medical Center of Utrecht, Utrecht, The Netherlands. A.Rothova@oogh.azu.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chorioretinitis / complications,  diagnosis*,  physiopathology
Eye Diseases / complications,  diagnosis*,  physiopathology
Female
Follow-Up Studies
HLA-A Antigens / analysis
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Vision Disorders / diagnosis*,  etiology,  physiopathology
Visual Acuity*
Vitreous Body / pathology*
Chemical
Reg. No./Substance:
0/HLA-A Antigens; 0/HLA-A29
Comments/Corrections
Comment In:
Ophthalmology. 2005 Mar;112(3):527-8; author reply 528   [PMID:  15745791 ]

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