Document Detail

Bipolar genome reductional division of human near-senescent, polyploid fibroblast cells.
MedLine Citation:
PMID:  17284369     Owner:  NLM     Status:  MEDLINE    
The rise in mitotic polyploid cells in near-senescence (phase III) of human fibroblast cells has been found to contain diplochromosomes (four chromatids). For tetraploid cells, this translates into 46 pairs of sister chromosomes. It has been suggested, from the increase in numbers of such cells, that they might deviate from expected normal, single chromatid segregations in mitosis. In this study, the polyploid cells with diplochromosomes were shown to segregate by bipolar mitosis into genome-reduced cells. Sister pairs separated from each other and moved as a genomic group of two-chromatid chromosomes to the poles. A tetraploid cell thus became reduced to two diploid cells (i.e., G2-4c in G1), which in the next mitosis could either restore the previous diplochromosomal status and ploidy level or cycle as diploid mitotic cells. The polyploid cells that are programmed for genome reductional division become part of the senescent cell population. In such populations, there is depolyploidization into multinucleated cells (MNCs) that can spawn genome-reduced mitotic offspring cells. These facts are relevant to neoplasticity-associated cytopathologies such as 4n cells as intermediates in Barrett's esophagus, MNCs in human papillomavirus infections, and radiation-associated cell changes. On a cell population level, the bipolar genome reductional division is a source for genetic heterogeneity, generating a continued mixture of polyploid and genome-reduced cells. The only other known case is in the mosquito, but the phenomenon is likely more common than has been thought.
Kirsten H Walen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  173     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Viral and Rickettsial Disease Laboratory, California Department of Health Services, 850 Marina Bay Parkway, Richmond, CA 94804, USA.
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MeSH Terms
Cell Aging
Cell Cycle / genetics
Cell Division / genetics
Cell Line
Chromosome Segregation
Fibroblasts / cytology,  metabolism*
Genome, Human*
Mitosis / genetics*
Neoplasms / genetics

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