Document Detail


Biphasic solitary fibrous tumour: a report of two cases with epithelioid features.
MedLine Citation:
PMID:  16244869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present two cases of solitary fibrous tumour (SFT) showing biphasic morphology with a spectrum of malignant epithelioid components. Slides prepared from formalin-fixed and paraffin-embedded tissue from both cases were stained with haematoxylin and eosin and by immunohistochemistry. Interphase fluorescent in situ hybridisation studies were performed in both cases using paraffin-embedded tissue to look for the t(X;18) translocation, thereby to exclude synovial sarcoma. Both cases showed biphasic morphology with some areas having typical benign spindled SFT morphology (including CD34 expression) and other areas having a malignant epithelioid appearance. In one of the cases, the epithelioid area, which was well circumscribed and showed packeting of cell groups, demonstrated expression of cytokeratin and epithelial cadherin but not of CD34. In the second case, the immunophenotype of the epithelioid component was similar to that of the benign SFT component. These findings suggest that epithelioid change in SFT shows a range of differentiation at one end, similar to that of a standard SFT, and at the other end, possibly acquiring epithelial characteristics.
Authors:
R Awasthi; J K O'Neill; C E Keen; P T L Sarsfield; V S Devaraj; C A Stone; M E F Smith
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-10-22
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  448     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-09     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  IM    
Affiliation:
Department of Histopathology, Royal Devon and Exeter Hospital, Barrack Road, Exeter, UK.
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MeSH Terms
Descriptor/Qualifier:
Cell Transformation, Neoplastic
DNA, Neoplasm / analysis
Diagnosis, Differential
Epithelioid Cells / chemistry,  pathology*
Female
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Sarcoma, Synovial / diagnosis
Soft Tissue Neoplasms / chemistry,  pathology*,  surgery
Solitary Fibrous Tumors / chemistry,  pathology*,  surgery
Tumor Markers, Biological / analysis
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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