| Biphasic shocks compared with monophasic damped sine wave shocks for direct ventricular defibrillation during open heart surgery. | |
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MedLine Citation:
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PMID: 12717126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Biphasic waveform shocks are more effective than monophasic shocks for transchest ventricular defibrillation, atrial cardioversion, and defibrillation with implantable defibrillators but have not been studied for open chest, intraoperative defibrillation. This prospective, blinded, randomized clinical study compares biphasic and monophasic shock effectiveness and establishes intraoperative energy dose-response curves. METHODS: Patients undergoing cardiothoracic surgery with bypass cardioplegia were randomly assigned to the monophasic or biphasic shock group. Ventricular fibrillation occurring after aortic clamp removal was treated with escalating energies of 2, 5, 7, 10, and 20 J until defibrillation occurred. If ventricular fibrillation persisted, a 20-J crossover shock of the other waveform was used. RESULTS: Cumulative defibrillation success at 5 J, the primary end point of the study, was higher in the biphasic group than in the monophasic group (25 of 50 vs. 9 of 41 defibrillated; P = 0.011). In addition, the biphasic group required lower threshold energy (6.8 vs. 11.0 J; P = 0.003), less cumulative energy (12.6 vs. 23.4 J; P = 0.002), and fewer shocks (2.5 vs. 3.5; P = 0.002). Crossover-shock effectiveness did not differ between groups. Dose-response curves show biphasic shocks to have higher cumulative success rates at all energies tested. CONCLUSIONS: Biphasic shocks are substantially more effective than monophasic shocks for direct defibrillation. The dose-response curve guides selection of first-shock energy for traditional step-up protocols. Starting at 5 J optimizes for lowest threshold and cumulative energy, whereas 10 or 20 J optimizes for more rapid defibrillation and fewer shocks. |
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Authors:
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Birgit Schwarz; T Andrew Bowdle; G Kimble Jett; Peter Mair; Karl H Lindner; Gabriel S Aldea; Robert G Lazzara; Sharon G O'Grady; Paul W Schmitt; Robert G Walker; Fred W Chapman; Willis A Tacker |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 98 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-28 Completed Date: 2003-07-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 1063-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Critical Care Medicine, University of Innsbruck, Austria. birgit.schwarz@uibk.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiac Surgical Procedures Coronary Artery Bypass / methods* Echocardiography, Transesophageal Electric Countershock* / methods Electrolytes / blood Female Humans Male Middle Aged Monitoring, Intraoperative Oxygen / blood Partial Pressure Prospective Studies Ventricular Fibrillation / surgery* |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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