| Biphasic increase in the in vivo phosphorylation of nuclear 110-kDa protein during early lymphocyte transformation. | |
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MedLine Citation:
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PMID: 2581775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A major 110-kDa phosphoprotein in rat liver and hepatoma (P 110) was identified in nuclear 0.2 M HCl extracts from rat lymph node cells. Stimulation with concanavalin A altered both the amount of P110 and, more strikingly, its in vivo phosphorylation in a typical biphasic manner with an initial maximum after 10-14 h. RNA synthesis showed a similar biphasic increase. Inhibition of hnRNA synthesis (5,6 dichlorobenzimidazoleriboside), but not of DNA synthesis (hydroxyurea), depressed both the amount of P110 and its phosphorylation markedly. |
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Authors:
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G Kostka; A Schweiger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 148 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-07-05 Completed Date: 1985-07-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 437-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / metabolism* Cell Nucleus / metabolism* Cells, Cultured Chemical Phenomena Chemistry Concanavalin A / pharmacology DNA / biosynthesis Hydrolysis Liver / metabolism* Liver Neoplasms Lymph Nodes Lymphocyte Activation* Molecular Conformation Peptide Hydrolases Phosphoproteins / isolation & purification* Phosphorylation RNA / biosynthesis Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Phosphoproteins; 11028-71-0/Concanavalin A; 63231-63-0/RNA; 9007-49-2/DNA; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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