Document Detail

Biphasic action of retinoids on gonadotropin receptor induction in rat granulosa cells in vitro.
MedLine Citation:
PMID:  2848166     Owner:  NLM     Status:  MEDLINE    
Vitamin A (retinol) has been held to be uniquely essential for normal vision and reproduction, all other functions being served by its metabolite retinoic acid. The inability of retinoic acid to maintain adequate serum progesterone is implicated as the cause of fetal resorption. The availability of lipoproteins is a major limiting factor in progesterone production and the ovarian expression of lipoprotein receptors is dependent on the action of luteinizing hormone (LH). Therefore, we investigated the effects of retinol and retinoic acid on LH receptor induction by ovarian cells in an attempt to determine the basis for the reported differences in the gonadal action of these two retinoids. Our results indicate that retinoic acid (10(-10) M) and retinol (10(-8) M) each synergistically enhance the ability of follicle stimulating hormone (FSH) to induce LH-receptors and to stimulate the formation of cyclic adenosine 3',5'-monophosphate (cAMP) and progesterone. However, at higher concentrations, both retinoids inhibited these effects of FSH. For every measured effect, retinoic acid was more potent than retinol. Since retinol is metabolized to retinoic acid in other tissues, these results suggest that retinoic acid may be the mediator of the action of retinol on the ovary and that retinol's unique effect on reproduction needs to be investigated further.
P Bagavandoss; A R Midgley
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  43     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1607-14     Citation Subset:  IM    
Department of Physiology, University of Michigan, Ann Arbor 48109.
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MeSH Terms
Cyclic AMP / metabolism
Diethylstilbestrol / pharmacology
Follicle Stimulating Hormone / pharmacology
Granulosa Cells / drug effects,  metabolism*
Progesterone / metabolism
Receptors, LH / biosynthesis*,  drug effects
Tretinoin / pharmacology*
Vitamin A / pharmacology*
Reg. No./Substance:
0/Receptors, LH; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 56-53-1/Diethylstilbestrol; 57-83-0/Progesterone; 60-92-4/Cyclic AMP; 9002-68-0/Follicle Stimulating Hormone

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