Document Detail


Bipartite structure of the ade3 locus of Saccharomyces cerevisiae.
MedLine Citation:
PMID:  324867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty ade3 mutants were examined with respect to their growth requirements, levels of the tetrahydrofolate interconversion enzymes, and/or map positions. Four deletions were detected. Mutations that result in a requirement for adenine and histidine map in one region of the locus; those which result in a requirement for adenine only map in a quite separate region of the locus, a region not disclosed in previous studies. No correlation was observed between growth properties of the strains and enzyme levels.
Authors:
E W Jones
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genetics     Volume:  85     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenine / metabolism
Alleles
Aminohydrolases / metabolism
Chromosome Deletion
Chromosome Mapping*
Formate-Tetrahydrofolate Ligase / metabolism
Glycine Hydroxymethyltransferase / metabolism
Histidine / metabolism
Methylenetetrahydrofolate Dehydrogenase (NADP) / metabolism
Mutation
Recombination, Genetic
Saccharomyces cerevisiae / metabolism,  ultrastructure*
Tetrahydrofolates
Chemical
Reg. No./Substance:
0/Tetrahydrofolates; 71-00-1/Histidine; 73-24-5/Adenine; EC 1.5.1.5/Methylenetetrahydrofolate Dehydrogenase (NADP); EC 2.1.2.1/Glycine Hydroxymethyltransferase; EC 3.5.4.-/Aminohydrolases; EC 6.3.4.3/Formate-Tetrahydrofolate Ligase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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