Document Detail


Biotransformations on steroid nucleus of bile acids.
MedLine Citation:
PMID:  9292932     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bile acids in mammals are all derivatives of 5 beta-cholan-26-oic acid. They represent the major quantitative pathway by which cholesterol is metabolized in the body. This article covers the microbial and enzymatic transformations of free, saturated bile acids, that kept unaltered the C-24 cyclopentane-perhydrophenantrene nucleus. The bile acids that have been considered include the primary cholic and chenodeoxycholic acids, the secondary deoxycholic and lithocholic acids as well as the relevant dehydrocholic, ursocholic and ursodeoxycholic acids. Among the bile acid biotransformations, attention is paid to reactions that lead to pharmaceutically significant compounds. This is the case of 7 alpha-hydroxy epimerization of chenodeoxycholic acid to ursodeoxycholic acid, currently used for cholesterol galistone dissolution therapy and in the treatment of cholestatic liver diseases. Emphasis has placed on reporting reactions that may be of general interest and on the practical aspects of work in the field of biotransformations.
Authors:
O Bortolini; A Medici; S Poli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Steroids     Volume:  62     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:    1997 Aug-Sep
Date Detail:
Created Date:  1998-01-13     Completed Date:  1998-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  564-77     Citation Subset:  IM    
Affiliation:
Dipartimento di Chimica, Universitá di Ferrara, Ferrara, Italy. brl@dns.unife.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / metabolism
Bile Acids and Salts / chemistry*,  metabolism*
Hydroxylation
Hydroxysteroid Dehydrogenases / metabolism
Oxidation-Reduction
Steroids / chemistry*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Steroids; EC 1.1.-/Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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