Document Detail


Biotransformations of steroid compounds by Chaetomium sp. KCH 6651.
MedLine Citation:
PMID:  19463686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biotransformations of steroid compounds: androstenedione, testosterone, progesterone, pregnenolone and DHEA using Chaetomium sp. 1 KCH 6651 strain as a biocatalyst were investigated. The microorganism proved capable of selective hydroxylation of the steroid substrates. Androstenedione was converted to 14alpha-hydroxyandrost-4-en-3,17-dione (in over 75% yield) and 6beta-hydroxyandrost-4-en-3,17-dione (in low yield), while testosterone underwent regioselective hydroxylation at 6beta position. Progesterone was transformed to a single product-6beta,14alpha-dihydroxypregnan-4-en-3,20-dione in high yield, whereas biotransformation of DHEA resulted in the formation of 7alpha-hydroxy derivative, which was subsequently converted to 7alpha-hydroxyandrost-4-en-3,17-dione.
Authors:
Tomasz Janeczko; Jadwiga Dmochowska-Gładysz; Edyta Kostrzewa-Susłow; Agata Białońska; Zbigniew Ciunik
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Publication Detail:
Type:  Journal Article     Date:  2009-03-04
Journal Detail:
Title:  Steroids     Volume:  74     ISSN:  1878-5867     ISO Abbreviation:  Steroids     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657-61     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland. janeczko13@interia.pl
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MeSH Terms
Descriptor/Qualifier:
Biotransformation
Chaetomium / metabolism*
Crystallography, X-Ray
Hydroxylation
Steroids / metabolism*
Substrate Specificity
Chemical
Reg. No./Substance:
0/Steroids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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