| Biotransformations of steroid compounds by Chaetomium sp. KCH 6651. | |
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MedLine Citation:
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PMID: 19463686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biotransformations of steroid compounds: androstenedione, testosterone, progesterone, pregnenolone and DHEA using Chaetomium sp. 1 KCH 6651 strain as a biocatalyst were investigated. The microorganism proved capable of selective hydroxylation of the steroid substrates. Androstenedione was converted to 14alpha-hydroxyandrost-4-en-3,17-dione (in over 75% yield) and 6beta-hydroxyandrost-4-en-3,17-dione (in low yield), while testosterone underwent regioselective hydroxylation at 6beta position. Progesterone was transformed to a single product-6beta,14alpha-dihydroxypregnan-4-en-3,20-dione in high yield, whereas biotransformation of DHEA resulted in the formation of 7alpha-hydroxy derivative, which was subsequently converted to 7alpha-hydroxyandrost-4-en-3,17-dione. |
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Authors:
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Tomasz Janeczko; Jadwiga Dmochowska-Gładysz; Edyta Kostrzewa-Susłow; Agata Białońska; Zbigniew Ciunik |
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Publication Detail:
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Type: Journal Article Date: 2009-03-04 |
Journal Detail:
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Title: Steroids Volume: 74 ISSN: 1878-5867 ISO Abbreviation: Steroids Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: United States |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland. janeczko13@interia.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biotransformation Chaetomium / metabolism* Crystallography, X-Ray Hydroxylation Steroids / metabolism* Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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