Document Detail

Biotransformation of some pyrazole derivatives to glutathione conjugates in rat liver subcellular fractions.
MedLine Citation:
PMID:  550118     Owner:  NLM     Status:  MEDLINE    
During incubation of antipyrine, but not amidopyrine, 4-aminoantipyrine and 4-leucylaminoantipyrine, with rat liver microsomaland cytosol fractions in the presence of NADPH-generating system a reactive metabolite, which binds with glutathione is formed. The chemical nature of the metabolically activated intermediate is not known; it is suggested that the putative reactive metabolite responsible for this binding could be an epoxide.
J Pachecka; K Krzywicka; W Bicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Polish journal of pharmacology and pharmacy     Volume:  31     ISSN:  0301-0244     ISO Abbreviation:  Pol J Pharmacol Pharm     Publication Date:    1979 Nov-Dec
Date Detail:
Created Date:  1980-10-24     Completed Date:  1980-10-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0366561     Medline TA:  Pol J Pharmacol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  623-31     Citation Subset:  IM    
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MeSH Terms
Antipyrine / metabolism
Cytochrome P-450 Enzyme System / metabolism
Epoxy Compounds / metabolism
Glutathione / metabolism*
Liver / metabolism*
Microsomes, Liver / metabolism
Pyrazoles / metabolism*
Styrenes / metabolism
Reg. No./Substance:
0/Epoxy Compounds; 0/Pyrazoles; 0/Styrenes; 60-80-0/Antipyrine; 70-18-8/Glutathione; 9035-51-2/Cytochrome P-450 Enzyme System

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