| Biotransformation of some pyrazole derivatives to glutathione conjugates in rat liver subcellular fractions. | |
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MedLine Citation:
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PMID: 550118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During incubation of antipyrine, but not amidopyrine, 4-aminoantipyrine and 4-leucylaminoantipyrine, with rat liver microsomaland cytosol fractions in the presence of NADPH-generating system a reactive metabolite, which binds with glutathione is formed. The chemical nature of the metabolically activated intermediate is not known; it is suggested that the putative reactive metabolite responsible for this binding could be an epoxide. |
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Authors:
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J Pachecka; K Krzywicka; W Bicz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Polish journal of pharmacology and pharmacy Volume: 31 ISSN: 0301-0244 ISO Abbreviation: Pol J Pharmacol Pharm Publication Date: 1979 Nov-Dec |
Date Detail:
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Created Date: 1980-10-24 Completed Date: 1980-10-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0366561 Medline TA: Pol J Pharmacol Pharm Country: POLAND |
Other Details:
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Languages: eng Pagination: 623-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipyrine / metabolism Biotransformation Cytochrome P-450 Enzyme System / metabolism Epoxy Compounds / metabolism Glutathione / metabolism* Liver / metabolism* Male Microsomes, Liver / metabolism Pyrazoles / metabolism* Rats Styrenes / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Epoxy Compounds; 0/Pyrazoles; 0/Styrenes; 60-80-0/Antipyrine; 70-18-8/Glutathione; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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