Document Detail

Biotransformation of salvianolic acid B by Fusarium oxysporum f. sp. Cucumerinum and its two degradation routes.
MedLine Citation:
PMID:  22908572     Owner:  NLM     Status:  In-Process    
Resting cells of Fusarium oxysporum f. sp. Cucumerinum (F. oxsporum) were used for the biotransformation of salvianolic acid B (Sal B). Three transformed products, isolithospermic acid, prolithospermic acid and danshensu, were identified on the basis of chemical and spectroscopic data. The stability of the two ester bonds of Sal B was studied and two degradation routes were found. In the biotransformation system, Sal B was transformed into isolithospermic acid first which was then converted into prolithospermic acid. In alkaline solutions, Sal B was transformed into lithospermic acid first which was then converted into prolithospermic acid. This is the first reports of the NMR spectra of isolithospermic acid and this result may indicate the metabolic pathways of Sal B in vivo.
Shidong Kan; Huimin Lin; Ji'an Li; Lei Shao; Daijie Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  7     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  885-8     Citation Subset:  IM    
Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.
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