Document Detail


Biotransformation of myrislignan by rat liver microsomes in vitro.
MedLine Citation:
PMID:  17964618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myrislignan (1), erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxy-3-methoxyphenyl) propan-1-ol, is a major acyclic neolignan in seeds of Myristica fragrans. Studies have suggested that myrislignan may deter feeding activity, but little is known about its metabolism. We investigated the biotransformation of myrislignan by rat liver microsomes in vitro. Seven metabolites were produced by liver microsomes from rats pre-treated with sodium phenobarbital. These were identified, using spectroscopic methods, as myrislignanometins A-G (2-8), respectively.
Authors:
Fei Li; Xiu-Wei Yang
Related Documents :
2110158 - Increase of a form of udp-glucuronyltransferase glucuronizing various phenolic xenobiot...
1489928 - Fluoranthene metabolism: human and rat liver microsomes display different stereoselecti...
4397778 - Genetic aspects of increase in rat liver aldehyde dehydrogenase induced by phenobarbital.
1537468 - Cytochrome p450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,...
8800598 - No difference in the proportion of insulin receptor exon 11 +/- isoform mrna in the liv...
7789338 - Glucocorticoid and/or glucocorticoid antagonist effects in inflammatory disease-suscept...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-26
Journal Detail:
Title:  Phytochemistry     Volume:  69     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  765-71     Citation Subset:  IM    
Affiliation:
The State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biotransformation
Lignans / chemistry,  isolation & purification,  pharmacokinetics*
Magnetic Resonance Spectroscopy / methods
Male
Microsomes, Liver / chemistry*,  metabolism*
Molecular Conformation
Myristica fragrans / chemistry
Rats
Rats, Sprague-Dawley
Seeds / chemistry
Stereoisomerism
Chemical
Reg. No./Substance:
0/Lignans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cell wall invertase-deficient miniature1 kernels have altered phytohormone levels.
Next Document:  An ellagitannin, n-butyl gallate, two aryltetralin lignans, and an unprecedented diterpene ester fro...