Document Detail

Biotransformation of myrislignan by rat liver microsomes in vitro.
MedLine Citation:
PMID:  17964618     Owner:  NLM     Status:  MEDLINE    
Myrislignan (1), erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxy-3-methoxyphenyl) propan-1-ol, is a major acyclic neolignan in seeds of Myristica fragrans. Studies have suggested that myrislignan may deter feeding activity, but little is known about its metabolism. We investigated the biotransformation of myrislignan by rat liver microsomes in vitro. Seven metabolites were produced by liver microsomes from rats pre-treated with sodium phenobarbital. These were identified, using spectroscopic methods, as myrislignanometins A-G (2-8), respectively.
Fei Li; Xiu-Wei Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-26
Journal Detail:
Title:  Phytochemistry     Volume:  69     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  765-71     Citation Subset:  IM    
The State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
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MeSH Terms
Lignans / chemistry,  isolation & purification,  pharmacokinetics*
Magnetic Resonance Spectroscopy / methods
Microsomes, Liver / chemistry*,  metabolism*
Molecular Conformation
Myristica fragrans / chemistry
Rats, Sprague-Dawley
Seeds / chemistry
Reg. No./Substance:

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