| Biotransformation of lisuride in the hemoglobin-free perfused rat liver and in the whole animal. | |
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MedLine Citation:
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PMID: 6113107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isolated rat livers were perfused with an oxygenated saline medium containing 14C-lisuride. Metabolites obtained in the bile and the perfusate were characterized as the glucuronide of hydroxylisuride and hydroxy, 2-oxo, monode-ethyl, dide-ethyl, N6-demethyl and monode-ethyl-N6-demethyl derivatives of lisuride. In addition, the metabolite patterns were examined in various tissue homogenates in vitro and also in the rat in vivo. Whereas dealkylation reactions occurred predominantly under in vitro conditions, the metabolite profile observed in vivo was similar to that found in the perfused liver system. The principal routes for biotransformation of lisuride in the intact rats as well as in the perfused rat liver are those through aromatic hydroxylation and subsequent conjugation with glucuronic acid. |
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Authors:
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T Toda; N Oshino |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Drug metabolism and disposition: the biological fate of chemicals Volume: 9 ISSN: 0090-9556 ISO Abbreviation: Drug Metab. Dispos. Publication Date: 1981 Mar-Apr |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421550 Medline TA: Drug Metab Dispos Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 108-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Ergolines / metabolism* Feces / analysis Glucuronates / metabolism Hemoglobins / physiology* Lisuride / metabolism* Liver / metabolism* Male Rats |
| Chemical | |
Reg. No./Substance:
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0/Ergolines; 0/Glucuronates; 0/Hemoglobins; 18016-80-3/Lisuride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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