| Biotransformation of imperatorin by Aspergillus flavus. | |
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MedLine Citation:
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PMID: 15217285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Imperatorin (1) was metabolized by Aspergillus flavus, in growth media, to give five metabolites. On the basis of their physical data, the structures of the five metabolites were elucidated as xanthotoxol (2), E-trichoclin (3), Z-trichoclin (4), E-imperatorin acid (5), and Z-imperatorin acid (6); among these, 4, 5, and 6 were characterized as new coumarins. The five metabolites 2-6 were tested for anti-hepatitis B virus activity in vitro and found to be less active than the parent compound 1. |
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Authors:
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Wen-Yuh Teng; Yu-Ling Huang; Ray-Ling Huang; Ren-Shih Chung; Chien-Chih Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of natural products Volume: 67 ISSN: 0163-3864 ISO Abbreviation: J. Nat. Prod. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-25 Completed Date: 2004-08-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1014-7 Citation Subset: IM |
Affiliation:
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Department of Agricultural Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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metabolism*,
pharmacology Aspergillus flavus / metabolism* Biotransformation Coumarins / chemistry Hepatitis B virus / metabolism Molecular Structure Psoralens / metabolism*, pharmacology Stereoisomerism Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Coumarins; 0/Psoralens; 482-44-0/imperatorin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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