Document Detail

Biotransformation of germacranolide from Onopordon leptolepies by Aspergillus niger.
MedLine Citation:
PMID:  22186324     Owner:  NLM     Status:  In-Data-Review    
Terpenes are present in the essential oils obtained from herbs and spices. They are produced by these plant species as a chemical defense mechanism against phytopathogenic microorganisms. Therefore, terpenes have attracted great attention in the food industry, e.g., they have been used in foods such as cheese as natural preservatives to prevent fungal growth. Herein, we describe the microbial transformation of onopordopicrin (1) by Aspergillus niger. Four product 11α H-dihydroonopordopicrin (2), 11β H-dihydroonopordopicrin (3), 3β-hydroxy-11β H-dihydroonopordopicrin (4), and 14-hydroxy-11β H-dihydroonopordopicrin (5) were obtained. Their structures were identified on the basis of chemical and spectroscopic data. All the four compounds were novel.
Akbar Esmaeili; Nasrin Moazami; Abdolhossein Rustaiyan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pakistan journal of pharmaceutical sciences     Volume:  25     ISSN:  1011-601X     ISO Abbreviation:  Pak J Pharm Sci     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426356     Medline TA:  Pak J Pharm Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, Tehran, Iran.
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