Document Detail

Biotransformation of the fungicides hexachlorobenzene and pentachloronitrobenzene.
MedLine Citation:
PMID:  7027636     Owner:  NLM     Status:  MEDLINE    
This overview of the metabolism of the fungicides hexachlorobenzene (HCB) and pentachloronitrobenzene (PCNB) indicates similarities in their pathways of biotransformation. Several metabolites of HCB and PCNB, such as chlorinated benzenes, the mercapturic acid, thiophenols, thioanisoles and phenols are identical. Both Fungicides initially react with glutathione, with elimination or of the chlorine of the nitro group respectively. The conjugate, S-(pentachlorophenyl)glutathione, is further metabolized by cleavage of the glutamate and glycine results and acetylation of the amino group of the cysteinyl moiety, to give the mercapturic acid N-acetyl-S-(pentachlorophenyl)cysteine, a major metabolite of HCB and PCNB in rats and rabbits respectively, which is further metabolized to simpler sulphur-containing products.
G Renner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  11     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-12-15     Completed Date:  1981-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  435-46     Citation Subset:  IM    
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MeSH Terms
Chlorobenzenes / metabolism*
Eggs / analysis
Fungicides, Industrial / metabolism*
Hexachlorobenzene / metabolism*
Nitrobenzenes / metabolism*
Plants / metabolism
Soil / analysis
Reg. No./Substance:
0/Chlorobenzenes; 0/Fungicides, Industrial; 0/Nitrobenzenes; 0/Soil; 118-74-1/Hexachlorobenzene; 82-68-8/quintozene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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