| Biotransformation and elimination of 1-nitropyrene in the isolated perfused lung: effects of pretreating rats with phenobarbitone, beta-naphthoflavone, benz(A)anthracene or their mixtures. | |
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MedLine Citation:
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PMID: 9772702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The isolated perfused rat lung (IPL) was perfused with 60 ml of recirculating Krebs-Ringer solution containing 150 micrograms of 1-nitropyrene (1-NP) for 1 h. The 1-NP was administered to the IPL by the intratracheal or intravascular route. At specific time points after 1-NP administration, perfusate samples were removed from the IPL and analysed for 1-NP and its metabolites by HPLC. Monohydroxynitropyrenes, dihydroxynitropyrenes and 1-NP were found to be present in the perfusate. The time course of 1-NP concentrations in the perfusate could be described by a one-compartment pharmacokinetic model. Pretreatment of rats with beta-naphthoflavone (BNF), benz(a) anthracene (BA) or a mixture of phenobarbitone (PB) and BNF (PB + BNF) significantly enhanced the metabolism of 1-NP and decreased the mean residence time (MRT) of 1-NP in the perfusate. Pretreatment of rats with these mixed-function oxidase inducers also increased significantly the absorption of 1-NP by the lung when it was administered intratracheally. In contrast, pretreatment of rats with PB did not appear to have any effect on the pharmacokinetics of 1-NP in the IPL. |
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Authors:
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F C Law; S X He; Y C Chui |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Yao xue xue bao = Acta pharmaceutica Sinica Volume: 31 ISSN: 0513-4870 ISO Abbreviation: Yao Xue Xue Bao Publication Date: 1996 |
Date Detail:
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Created Date: 1998-11-12 Completed Date: 1998-11-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 21710340R Medline TA: Yao Xue Xue Bao Country: CHINA |
Other Details:
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Languages: eng Pagination: 568-76 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benz(a)Anthracenes / pharmacology Biotransformation Enzyme Inhibitors / pharmacology Lung / metabolism* Male Mutagens / pharmacokinetics* Perfusion Phenobarbital / pharmacology Pyrenes / pharmacokinetics* Rats Rats, Wistar beta-Naphthoflavone / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Benz(a)Anthracenes; 0/Enzyme Inhibitors; 0/Mutagens; 0/Pyrenes; 50-06-6/Phenobarbital; 5522-43-0/1-nitropyrene; 56-55-3/benz(a)anthracene; 6051-87-2/beta-Naphthoflavone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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