Document Detail

Biotransformation of carotenoids to retinal by carotenoid 15,15'-oxygenase.
MedLine Citation:
PMID:  20717662     Owner:  NLM     Status:  MEDLINE    
Retinal, a precursor of vitamin A, has been used in foods, cosmetics, pharmaceuticals, nutraceuticals, and animal feed additives. Carotenoid 15,15'-oxygenases, including β-carotene 15,15'-oxygenases from mammalians, chickens, fruit flies, zebrafishes, the uncultured marine bacterium, and the fungus Fusarium fujikuroi, and apo-carotenoid 15,15'-oxygenases from cyanobacteria produce retinal from carotenoids. In this article, the biochemical properties, reaction mechanism, and substrate specificity of carotenoid oxygenases are reviewed, along with a description of the enzymatic biotransformation of carotenoids to retinal. Retinal producing methods using metabolically engineered cells and uncharacterized proteins are suggested.
Yeong-Su Kim; Deok-Kun Oh
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-18
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  88     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-23     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  807-16     Citation Subset:  IM    
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
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MeSH Terms
Cyanobacteria / metabolism
Fusarium / metabolism
Oxygenases / metabolism*
Retinaldehyde / metabolism*
Substrate Specificity
Vitamin A / metabolism
beta Carotene / chemistry,  metabolism*
Reg. No./Substance:
11103-57-4/Vitamin A; 116-31-4/Retinaldehyde; 7235-40-7/beta Carotene; EC 1.13.-/Oxygenases; EC 1.13.-/carotenoid oxygenase

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