Document Detail


Biotransformation of the anticholinesterase agent, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
MedLine Citation:
PMID:  2070431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biotransformation of the anticholinesterasic agent 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine was studied in the laboratory rat. In the animal urine, the main identified metabolites were 9-amino-7-hydroxy-1,2,3,4-tetrahydroacridine and its conjugate with glucuronic acid, or sulfuric acid, as well as 9-amino-1-hydroxy-7-methoxy-1,2,3,4-tetrahydroacridine and 9-amino-2-hydroxy-7-methoxy-1,2,3,4-tetrahydroacridine. A part of the drug was excreted in an unchanged form.
Authors:
J Patocka; J Bielavský
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Ceskoslovenská farmacie     Volume:  40     ISSN:  0009-0530     ISO Abbreviation:  Cesk Farm     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-16     Completed Date:  1991-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372720     Medline TA:  Cesk Farm     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  cze     Pagination:  130-2     Citation Subset:  IM    
Affiliation:
Vojenská lékarská akademie J.E. Purkynĕ, Hradec Králové.
Vernacular Title:
Biotransformacní studie anticholinesterazika 9-amino-7-methoxy-1,2,3,4-tetrahydroakridinu.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotransformation
Male
Rats
Rats, Inbred Strains
Tacrine / analogs & derivatives*,  pharmacokinetics
Chemical
Reg. No./Substance:
321-64-2/Tacrine; 5778-80-3/7-methoxytacrine

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