Document Detail


Biotin uptake by basolateral membrane vesicles of human placenta: normal characteristics and role of ethanol.
MedLine Citation:
PMID:  7521055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed the mechanism of uptake of biotin by the fetal-facing (basolateral) membrane of the term human placenta. Using membrane vesicles, we showed that most of the uptake was attributable to transfer of the vitamin into the vesicle and that the uptake was saturable, Na-dependent, carrier-mediated, and electroneutral. The rate of uptake was less than for biotin uptake by the maternal-facing (apical) membrane of the human placenta. Because ethanol inhibits biotin uptake by the apical membrane, the effect of ethanol on uptake by basolateral vesicles was investigated. With 10-hr exposure at a concentration of 2 and 3 mg/ml, but not 1 mg/ml, ethanol modestly inhibited biotin uptake. The mechanism of inhibition by alcohol is not known.
Authors:
Z Q Hu; G I Henderson; D M Mock; S Schenker
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  206     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-23     Completed Date:  1994-09-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  404-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7878.
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MeSH Terms
Descriptor/Qualifier:
Biotin / analogs & derivatives,  pharmacokinetics*,  pharmacology
Cell Membrane / drug effects,  metabolism*
Ethanol / pharmacology*
Female
Gramicidin / pharmacology
Humans
Kinetics
Lysine / analogs & derivatives,  pharmacology
Mannitol
Membrane Potentials / drug effects
Osmolar Concentration
Placenta / drug effects,  metabolism*
Valinomycin / pharmacology
Grant Support
ID/Acronym/Agency:
NIAAA RO1 AA07514/AA/NIAAA NIH HHS; NIDDK RO1-36823/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
1405-97-6/Gramicidin; 15720-25-9/desthiobiotin; 2001-95-8/Valinomycin; 56-87-1/Lysine; 576-19-2/biocytin; 58-85-5/Biotin; 64-17-5/Ethanol; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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