Document Detail

Biotin-rich intranuclear inclusions in morule-lacking adenocarcinoma of the gallbladder: a new category of "neoplastic/non-morular" lesions.
MedLine Citation:
PMID:  15647941     Owner:  NLM     Status:  MEDLINE    
Biotin-rich intranuclear inclusions, also called "optically clear nuclei," are observed in various neoplastic and non-neoplastic lesions, including pregnancy-related endometrium and benign and malignant neoplasms with morular structures. A recent study reported that lesions with biotin-rich intranuclear inclusions can be classified as "(non-neoplastic) pregnancy-related endometrial" and as "(neoplastic) morular" category. In the present report, we describe two cases of well-differentiated adenocarcinoma of the gallbladder in which biotin-rich intranuclear inclusions were found without morular structures. Immunohistochemically, as reported previously, the intranuclear inclusions were positive for biotin and two biotin-binding enzymes (pyruvic acid carboxylase and propionyl CoA carboxylase). Intranuclear expression of beta-catenin was also observed in neoplastic cells with and without intranuclear inclusion. We also detected a frame shift mutation of APC gene in one case but no mutation of beta-catenin gene in both cases. Although intranuclear expression of beta-catenin by mutation of APC gene might contribute to carcinogenesis in our cases, the relationships among intranuclear expressions of beta-catenin, biotin, biotin-binding enzymes and intranuclear inclusions remain unclear. Our cases are the first neoplastic lesions with biotin-rich intranuclear inclusions that lacked morular structures. We propose a new "neoplastic/non-morular" category for lesions with biotin-rich intranuclear inclusions.
Yasuhiko Kimura; Kenji Kashima; Tsutomu Daa; Yoshiyuki Kondo; Kazuhiro Yada; Atsushi Sasaki; Toshifumi Matsumoto; Seigo Kitano; Nobuhiro Kubo; Shigeo Yokoyama
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-01-13
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  446     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-28     Completed Date:  2005-05-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  194-9     Citation Subset:  IM    
Department of Pathology, Faculty of Medicine, Oita University, Hasama-machi, 879-5593, Oita, Japan.
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MeSH Terms
Adenocarcinoma / chemistry*,  genetics,  pathology*
Biotin / analysis*
Cell Nucleus / chemistry*
Cytoskeletal Proteins / analysis,  genetics
DNA Mutational Analysis
Frameshift Mutation
Gallbladder Neoplasms / chemistry*,  genetics,  pathology*
Methylmalonyl-CoA Decarboxylase / analysis
Mucin 5AC
Mucins / analysis
Pyruvate Carboxylase / analysis
Trans-Activators / analysis,  genetics
beta Catenin
Reg. No./Substance:
0/CTNNB1 protein, human; 0/Cytoskeletal Proteins; 0/MUC5AC protein, human; 0/MUC6 protein, human; 0/Mucin 5AC; 0/Mucin-6; 0/Mucins; 0/Trans-Activators; 0/beta Catenin; 58-85-5/Biotin; EC Decarboxylase; EC Carboxylase

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