| BIOTIN DEFICIENCY AND OTHER CHANGES IN RATS GIVEN SULFANILYLGUANIDINE OR SUCCINYL SULFATHIAZOLE IN PURIFIED DIETS. | |
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MedLine Citation:
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PMID: 17751369 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The following pathological changes have been observed in rats given sulfaguanidine or sulfasuxidine in purified diets. 1. A granulocytopenia, leukopenia, hypocellularity of bone marrow and, occasionally, an anemia. 2. Hyalinization, necrosis and calcification of voluntary muscle. 3. Hyaline sclerosis and calcification of blood vessels. 4. A dermatitis which can be prevented or successfully treated with crystalline biotin. We have also observed necrosis of heart muscle, hemorrhage into various organs and subcutaneous tissues, and liver damage. |
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Authors:
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F S Daft; L L Ashburn; W H Sebrell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 96 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1942 Oct |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 321-2 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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