| Biotin-conjugated polychelating agent. | |
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MedLine Citation:
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PMID: 9893977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A procedure is described for preparing a polychelating agent-biotin conjugate through the interaction of biotin-maleimide with poly-L-lysine modified with multiple residues of diethylenetriaminepentaacetic acid and containing amino-terminal pyridylthio-propionate group. The conjugate can be easily loaded with multiple metal atoms, such as 111In, and preserves its ability to specifically interact with avidin (as avidin-agarose). Polychelate-biotin conjugate may be used for signal amplification in visualization and analytical protocols involving the application of the avidin-biotin system. |
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Authors:
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V P Torchilin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioconjugate chemistry Volume: 10 ISSN: 1043-1802 ISO Abbreviation: Bioconjug. Chem. Publication Date: 1999 Jan-Feb |
Date Detail:
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Created Date: 1999-03-29 Completed Date: 1999-03-29 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 146-9 Citation Subset: IM |
Affiliation:
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Center for Imaging and Pharmaceutical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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chemistry Biotin / chemistry* Chelating Agents / chemical synthesis, chemistry* Chromatography, Ion Exchange Indium Radioisotopes Maleimides Pentetic Acid / chemistry Polylysine / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Chelating Agents; 0/Indium Radioisotopes; 0/Maleimides; 25104-18-1/Polylysine; 58-85-5/Biotin; 67-43-6/Pentetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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