Document Detail


Biotin and carnitine profiles in preterm infants in Japan.
MedLine Citation:
PMID:  23316835     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β-oxidation to transport long-chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in preterm infants who received enteral feeding with maternal milk and/or standard infant formula made in Japan. METHODS: Forty-six infants were enrolled in the study. Urine and serum samples and dried blood spots were collected at 1 week and 1 month of age. Additionally, samples were collected at 40 and 44 weeks post-menstrual age (PMA) in preterm infants. Free carnitine (C0) and C5-OH acylcarnitine (C5-OH), which consist of 3-hydroxyisovalerylcarnitine as a major isomer, were measured in serum samples and dried blood spots using tandem mass spectrometry (MS/MS). Urine 3-hydroxyisovaleric acid (3-HIVA) was measured using gas chromatography/mass spectrometry (GC/MS). RESULTS: The free carnitine levels in preterm infants were significantly lower than those in term infants, but increased with PMA in serum samples and dried blood spots. C5-OH acylcarnitine and urinary 3-HIVA levels, which were very low in term infants, were increased with PMA in preterm infants. CONCLUSION: The present results may indicate chronic biotin deficiency in preterm infants fed maternal milk and/or standard infant formula. Analyses of carnitine profiles of dried blood spots and urine 3-HIVA are relatively non-invasive and useful for the early detection of biotin deficiency in preterm infants.
Authors:
Shuko Tokuriki; Hisako Hayashi; Takashi Okuno; Kikuko Yoshioka; Shintaro Okazaki; Akiko Kawakita; Genrei Ota; Ikue Hata; Yosuke Shigematsu; Yusei Oshima
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-14
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.
Affiliation:
Department of Pediatrics, Faculty of Medical Sciences, University of Fukui.
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