| Biotherapeutic agents in the treatment of infectious diarrhea. | |
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MedLine Citation:
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PMID: 11586560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biotherapeutic agents offer unique advantages over traditional treatments for infectious diarrhea, and several have been shown to be effective (Table 4). These therapeutic microbial agents are most effective in types of infectious diseases that are associated with a disruption of the normal intestinal microecology (e.g., AAD, C. difficile disease). The impact of biotherapeutic agents on rotaviral diarrhea is of special clinical importance because this is the most common cause of pediatric diarrhea, and there is no defined treatment. Strong efforts need to be made to limit antibiotic exposure in children. Biotherapeutic agents offer a safe and effective nonantibiotic method of treating this important pathogen, especially after the withdrawal of a rotaviral vaccine from the market by the FDA. However, for many biotherapeutic agents, well-done, placebo-controlled trials still are lacking, and not all types of infectious diarrhea respond to these agents. Continued research in this innovative therapeutic area is warranted. |
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Authors:
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G W Elmer; L V McFarland |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Gastroenterology clinics of North America Volume: 30 ISSN: 0889-8553 ISO Abbreviation: Gastroenterol. Clin. North Am. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-10-05 Completed Date: 2002-01-23 Revised Date: 2006-04-13 |
Medline Journal Info:
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Nlm Unique ID: 8706257 Medline TA: Gastroenterol Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 837-54 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, USA. elmer@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child, Preschool Diarrhea / drug therapy*, etiology, prevention & control Enterococcus faecium Humans Infant Lactobacillus acidophilus Probiotics / therapeutic use* Saccharomyces Travel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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