Document Detail


Biotechnological prospects from metagenomics.
MedLine Citation:
PMID:  12849784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recognition that most microorganisms in the environment cannot be cultured by standard methods stimulated the development of metagenomics, which is the genomic analysis of uncultured microorganisms. Two types of analysis have been used to obtain information from metagenomic libraries: a function-driven approach, in which metagenomic libraries are initially screened for an expressed trait, and a sequence-driven approach, in which libraries are initially screened for particular DNA sequences. New antibiotics and enzymes are among the early discoveries from metagenomics. Future refinement of methods that enrich for genes of particular function will accelerate the rate of discovery of useful molecules.
Authors:
Patrick D Schloss; Jo Handelsman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  14     ISSN:  0958-1669     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2004-04-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-10     Citation Subset:  IM    
Affiliation:
Department of Plant Pathology, Russell Laboratories, University of Wisconsin, 1630 Linden Drive, Madison, WI 53706, USA.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / biosynthesis*,  genetics
Biotechnology / methods*
Cloning, Molecular / methods*
Drug Design
Gene Expression Regulation, Bacterial / physiology*
Genomics / methods*
Metabolism / physiology
Peptide Library*
Protein Engineering / methods
Recombinant Proteins / biosynthesis*,  genetics
Sequence Analysis, Protein / methods*
Soil Microbiology
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Peptide Library; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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