Document Detail

Biotechnological production of enantiomeric pure lactic acid from renewable resources: recent achievements, perspectives, and limits.
MedLine Citation:
PMID:  19826806     Owner:  NLM     Status:  MEDLINE    
Lactic acid (LA) is an important and versatile chemical that can be produced from renewable resources such as biomass. LA is used in the food, pharmaceutical, and polymers industries and is produced by microorganism fermentation; however, most microorganisms cannot directly utilize biomass such as starchy materials and cellulose. Here, we summarize LA production using several kinds of genetically modified microorganisms, such as LA bacteria, Escherichia coli, Corynebacterium glutamicum, and yeast. Using gene manipulation and metabolic engineering, the yield and optical purity of LA produced from biomass has been significantly improved. In this review, the drawbacks as well as improvements of LA production by fermentation is discussed.
Kenji Okano; Tsutomu Tanaka; Chiaki Ogino; Hideki Fukuda; Akihiko Kondo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  85     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-07     Completed Date:  2010-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  413-23     Citation Subset:  IM    
Department of Molecular Science and Material Engineering, Graduate School of Science and Technology, Kobe University, 1-1 Rokkodaicho, Nada-ku, Kobe, Japan.
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MeSH Terms
Bacteria / genetics,  metabolism
Biotechnology / methods*
Genetic Engineering
Industrial Microbiology / methods*
Lactic Acid / chemistry,  metabolism*
Metabolic Networks and Pathways / genetics
Yeasts / genetics,  metabolism
Reg. No./Substance:
50-21-5/Lactic Acid

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