Document Detail


Biosynthetic origin of the 3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid moiety and absolute configuration of pahayokolides A and B.
MedLine Citation:
PMID:  21650153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pahayokolides A and B are cyclic undecapeptides that were isolated from the cyanobacterium Lyngbya sp. They contain the unusual α-hydroxy-β-amino acid 3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid (Athmu). The absolute configurations of the amino acids of the pahayokolides, except for the four oxygen-bearing stereocenters of Athmu, have been determined by Marphy's method. Incorporation of labeled leucine and acetate precursors into the pahayokolides has established that Athmu is derived from a leucine or α-keto isocaproic acid starter unit, which is further extended with three acetate units.
Authors:
Li Liu; Daniel W Bearden; Kathleen S Rein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-08
Journal Detail:
Title:  Journal of natural products     Volume:  74     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-24     Completed Date:  2011-10-03     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1535-8     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA.
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MeSH Terms
Descriptor/Qualifier:
Cyanobacteria / chemistry
Fatty Acids / biosynthesis,  chemistry*
Lyngbya Toxins / chemistry*
Molecular Structure
Peptides, Cyclic / chemistry,  isolation & purification*
Grant Support
ID/Acronym/Agency:
S11 ES011181/ES/NIEHS NIH HHS; S11 ES011181-10/ES/NIEHS NIH HHS; S11 ES11181/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid; 0/Fatty Acids; 0/Lyngbya Toxins; 0/Peptides, Cyclic; 0/pahayokolide A; 0/pahayokolide B
Comments/Corrections

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