| Biosynthetic origin of the 3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid moiety and absolute configuration of pahayokolides A and B. | |
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MedLine Citation:
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PMID: 21650153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pahayokolides A and B are cyclic undecapeptides that were isolated from the cyanobacterium Lyngbya sp. They contain the unusual α-hydroxy-β-amino acid 3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid (Athmu). The absolute configurations of the amino acids of the pahayokolides, except for the four oxygen-bearing stereocenters of Athmu, have been determined by Marphy's method. Incorporation of labeled leucine and acetate precursors into the pahayokolides has established that Athmu is derived from a leucine or α-keto isocaproic acid starter unit, which is further extended with three acetate units. |
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Authors:
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Li Liu; Daniel W Bearden; Kathleen S Rein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-08 |
Journal Detail:
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Title: Journal of natural products Volume: 74 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-24 Completed Date: 2011-10-03 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1535-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyanobacteria
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chemistry Fatty Acids / biosynthesis, chemistry* Lyngbya Toxins / chemistry* Molecular Structure Peptides, Cyclic / chemistry, isolation & purification* |
| Grant Support | |
ID/Acronym/Agency:
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S11 ES011181/ES/NIEHS NIH HHS; S11 ES011181-10/ES/NIEHS NIH HHS; S11 ES11181/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid; 0/Fatty Acids; 0/Lyngbya Toxins; 0/Peptides, Cyclic; 0/pahayokolide A; 0/pahayokolide B |
| Comments/Corrections | |
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