| BIOSYNTHESIS OF RIBOFLAVINE BY A PURINE-REQUIRING MUTANT STRAIN OF ESCHERICHIA COLI. | |
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MedLine Citation:
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PMID: 14340067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Riboflavine biosynthesis occurs in non-proliferating cultures of a purine-requiring strain of Escherichia coli (ATCC no. 13863). 2. No significant incorporation of radioactivity from [1-(14)C]glycine into either C-4a and C-9a of riboflavine or into nucleic acid purines is detected under the above conditions; appreciable incorporation of label into 5-aminoimidazole-4-carboxamide occurs. However, the label of [6-(14)C]guanine is incorporated significantly into C-4 of riboflavine and into nucleic acid adenine and guanine; the specific radioactivity of the riboflavine is approximately twice that of either adenine or guanine of nucleic acid. 3. These results show that a purine derivative is an obligatory intermediate in riboflavine biogenesis. |
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Authors:
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D J HOWELLS; G W PLAUT |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 94 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1965 Mar |
Date Detail:
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Created Date: 1965-12-01 Completed Date: 1996-12-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 755-9 Citation Subset: OM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Escherichia coli* Glycine* Guanine* Imidazoles* Metabolism* Mutation* Purines* Research* Riboflavin* |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Purines; 56-40-6/Glycine; 73-40-5/Guanine; 83-88-5/Riboflavin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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