Document Detail


BIOSYNTHESIS OF RIBOFLAVINE BY A PURINE-REQUIRING MUTANT STRAIN OF ESCHERICHIA COLI.
MedLine Citation:
PMID:  14340067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Riboflavine biosynthesis occurs in non-proliferating cultures of a purine-requiring strain of Escherichia coli (ATCC no. 13863). 2. No significant incorporation of radioactivity from [1-(14)C]glycine into either C-4a and C-9a of riboflavine or into nucleic acid purines is detected under the above conditions; appreciable incorporation of label into 5-aminoimidazole-4-carboxamide occurs. However, the label of [6-(14)C]guanine is incorporated significantly into C-4 of riboflavine and into nucleic acid adenine and guanine; the specific radioactivity of the riboflavine is approximately twice that of either adenine or guanine of nucleic acid. 3. These results show that a purine derivative is an obligatory intermediate in riboflavine biogenesis.
Authors:
D J HOWELLS; G W PLAUT
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  94     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1965 Mar 
Date Detail:
Created Date:  1965-12-01     Completed Date:  1996-12-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  755-9     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Escherichia coli*
Glycine*
Guanine*
Imidazoles*
Metabolism*
Mutation*
Purines*
Research*
Riboflavin*
Chemical
Reg. No./Substance:
0/Imidazoles; 0/Purines; 56-40-6/Glycine; 73-40-5/Guanine; 83-88-5/Riboflavin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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