Document Detail

Biosynthesis of prostaglandin E2 and F2 alpha in gingiva of patients with chronic periodontitis.
MedLine Citation:
PMID:  6937509     Owner:  NLM     Status:  MEDLINE    
The biosynthesis of radioactive prostaglandin E2 (PGE2) and F2 alpha from (1-14C) arachidonic acid has been demonstrated in the microsomal fraction of gingiva of patients with chronic periodontitis in vitro. 14C corresponding to unmetabolized arachidonic acid in three separate incubations was 83, 66, and 83%, and that corresponding to both PGE2 and PGF2 alpha was 8, 22, and 9% of the total radioactivity recovered after chromatography. The ratios of PGE2 to PGF2 alpha were found to be 6:1, 6:1, and 3:1, respectively.
T M Elattar; H S Lin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of dental research     Volume:  60     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  748-50     Citation Subset:  D; IM    
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MeSH Terms
Arachidonic Acids / metabolism
Gingiva / metabolism*
Microsomes / metabolism
Periodontitis / metabolism*
Prostaglandins E / biosynthesis*
Prostaglandins F / biosynthesis*
Grant Support
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins E; 0/Prostaglandins F

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