| Biosynthesis and production of polysialic acids in bacteria. | |
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MedLine Citation:
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PMID: 20349183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polysialic acids (PA) are protective capsular sialohomopolymers present in some bacteria which can invade the mammalian host and cause lethal bacteremia and meningitis. Biosynthesis and translocation of PA to the cell surface are equivalent in different species and bacterial strains which are produced. The diversity in PA structure is derived from the PA linkages and is a consequence of the specific sialyltransferase activities. The monomer acetylation and the polymer length could be important factors in the potential virulence. In vivo PA production is affected by different physical and chemical factors. The temperature of cellular growth strictly regulates PA genesis through a molecular complex and multifactorial mechanism that operate to transcription level. |
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Authors:
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Miguel Angel Ferrero; Leandro Rodríguez Aparicio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-03-27 |
Journal Detail:
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Title: Applied microbiology and biotechnology Volume: 86 ISSN: 1432-0614 ISO Abbreviation: Appl. Microbiol. Biotechnol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406612 Medline TA: Appl Microbiol Biotechnol Country: Germany |
Other Details:
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Languages: eng Pagination: 1621-35 Citation Subset: IM |
Affiliation:
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Departamento de Biología Molecular, Universidad de León, Campus de Vegazana, 24071, León, Spain. ma.ferrero@unileon.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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genetics,
metabolism*,
pathogenicity Genes, Bacterial Metabolic Networks and Pathways Polysaccharides, Bacterial / biosynthesis*, chemistry, metabolism Sialic Acids / biosynthesis*, chemistry, metabolism Temperature Virulence |
| Chemical | |
Reg. No./Substance:
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0/Polysaccharides, Bacterial; 0/Sialic Acids; 0/polysialic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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