Document Detail

Biosynthesis and production of polysialic acids in bacteria.
MedLine Citation:
PMID:  20349183     Owner:  NLM     Status:  MEDLINE    
Polysialic acids (PA) are protective capsular sialohomopolymers present in some bacteria which can invade the mammalian host and cause lethal bacteremia and meningitis. Biosynthesis and translocation of PA to the cell surface are equivalent in different species and bacterial strains which are produced. The diversity in PA structure is derived from the PA linkages and is a consequence of the specific sialyltransferase activities. The monomer acetylation and the polymer length could be important factors in the potential virulence. In vivo PA production is affected by different physical and chemical factors. The temperature of cellular growth strictly regulates PA genesis through a molecular complex and multifactorial mechanism that operate to transcription level.
Miguel Angel Ferrero; Leandro Rodríguez Aparicio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-27
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  86     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1621-35     Citation Subset:  IM    
Departamento de Biología Molecular, Universidad de León, Campus de Vegazana, 24071, León, Spain.
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MeSH Terms
Bacteria / genetics,  metabolism*,  pathogenicity
Genes, Bacterial
Metabolic Networks and Pathways
Polysaccharides, Bacterial / biosynthesis*,  chemistry,  metabolism
Sialic Acids / biosynthesis*,  chemistry,  metabolism
Reg. No./Substance:
0/Polysaccharides, Bacterial; 0/Sialic Acids; 0/polysialic acid

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